BMJ: Study on the risk of leaching breast cancer and breast cancer death in patients with breast catheter in situ cancer

Researchers recently examined the long-term risk of breast cancer and death from breast cancer after screening for breast catheterining in symfire (DCIS)study using NHS breast screening programme and national cancer registration data, a total of 3,524 women had DCIS between 1988 and March 2014The main endpoints of the study were invasive breast cancer and breast cancer deaths13,606 women received follow-up for five years, 1,998 women for five to nine years, 6,861 women for 10-14 years, 2,620 for 15-19 years and 939 for at least 20 yearsOf these women, 2,076 had invasive breast cancer, with a corresponding incidence rate of 8.82 per 1,000 women per year, more than twice the expected incidence of breast cancer in the country (2.52), with the increased risk beginning in the second year after DCIS diagnosis and continued until the end of the follow-up310 people die from breast cancer, with a corresponding mortality rate of 1.26 per 1,000 women per year, which is 70% higher than the national breast cancer mortality rate expected ( 1.70)。 In the first five years after DCIS diagnosis, the mortality rate for breast cancer was similar to the expected national mortality rate (0.87), but subsequently increased, with breast cancer mortality rates of 1.98, 2.99 and 2.77, respectively, 5-9, 10-14 and 15 years after DCIS diagnosisAmong the 29,044 women who underwent single-sided DCIS surgery, patients who received more intensive treatment, such as mastectomy, post-mastulate radiation therapy, and estrogen receptor-positive patients, had a lower incidence of invasive breast cancerstudies suggest that women who were screened for in-situ breast cancer had a higher risk of invasive breast and breast cancer death than the general population for at least 20 years after diagnosis