BMJ JNNP: The light paraplegia pattern of ALS is consistent with the physiological projection of the cortex nerve gel in different muscle groups.

!---- The most recent staging method used molecularly labeled phosphorylation 43 kDa TAR DNA binding proteins (pTDP-43) to treat endemic amyotrophic lateral sclerosis (ALS), suggesting that the disease progresses in the development of cyber diseases by predictable sequence anatomical patterns to identify specific areas of the brain and spinal cord. Clinically, this pathological pattern of distributive ALS indicates that alpha-motor neurons are more likely to experience loss of function and muscle atrophy than the muscle groups provided by alpha-motor neurons with strong CM connectivity in CM patients. the existence and distribution ofcerebral cortex neural network (CM) connection is of great significance to the systematic development of primate hand skills., the dexterous primate's inherent and outer hand muscles are directly controlled by the motor cortex.method: In one case group (N - 436), the authors reviewed muscle paralysis patterns in ALS patients using the British Medical Research Council (MRC) scoring system., the authors then conducted two separate prospective studies in two smaller groups (N - 92 and N - 54).61 per cent of women and 39 per cent of women, with an average age of 56.5 years and a median survival period of 45.5 months.42 (9.6%) had a positive family history, 24 percent had elongated myelin and 76 percent of spina encephalitis.each patient meets El Escorial's ALS standards, including possible ALS.29 If several tests are performed, the first test is performed and all muscle groups are tested in this case.results: The results show the presence of characteristic light paralysis.when comparing muscle groups in patients, the muscle groups that received more obvious CM connections were known to be significantly weaker.in patients, the thumb extechoal muscle is larger than the elbow extension muscle, the flexor muscle relative to the flexor of the hand, and the elbow flexor relative to the muscle weakness (MRC score is lower).in the lower limbs, the knee flexor is weaker than the elongation muscle, and the foot-stretching muscle is weaker than the foot.for all six pairs of muscles tested, most of these findings make sense (p.lt;0.01) and indirectly support the idea that ALS may specifically affect muscle groups with strong CM connections.this particular model can help refine clinical and electrophysiological ALS diagnostic criteria and complement prospective clinical pathology correlation studies.original links: Ludolph AC, Emilian S, Dreyhaupt J, et al Pattern of Paresis in alS is with the physiology of the corticomotoneuronal projections to the different groups of groups of the journal of The S. Curry and Prinse Pritonline First: 14 July 2020. doi: 10.1136/jnnp-2020-323331MedSci Original Source: MedSci Original, !-- Content Show Ends - !-- Determine Stoding Ends.