BMC: Mulberry leaf ethanol extract can lower blood sugar levels in type 2 diabetes

Due to the increase of the aging population and the acceleration of urbanization, the prevalence of diabetes is expanding worldwide, which has a major negative impact on personal health and has brought a major economic burden to the public medical system
.

90% of cases are type 2 diabetes (T2DM), which is a progressive disease

Studies have shown that in addition to the typical blood glucose imbalance characteristics, T2DM may also cause other serious long-term complications, such as macrovascular disease, microvascular disease, and neuropathy
.

Currently, for T2DM treatment, 50% of patients require a combination of two or more non-insulin drugs, and one-third of patients will require insulin to lower blood sugar

For T2DM treatment, 50% of patients require a combination of two or more non-insulin drugs, and one-third of patients will require insulin to lower blood sugar

Traditional Chinese medicines such as Xiaoke Pills and Rhubarb Huanglian Xiexin Decoction (DHXD) can lower blood sugar levels and/or reduce weight, while improving other T2DM symptoms.

Hepatic glycogen plays an important role in blood glucose homeostasis
.

During the progression of T2DM, liver glycogen accumulation and metabolism both undergo abnormal changes

Hepatic glycogen plays an important role in blood glucose homeostasis

The method is that in the research, firstly, the biologically active components of the ethanol extract of mulberry leaf were determined by high performance liquid chromatography (HPLC) and liquid chromatography/mass spectrometry (LC/MS)
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The mouse animal models were divided into three groups, normal Sprague-Dawley (SD) rats, high-fat diet (HFD) and streptozotocin (STZ) induced type 2 diabetic rats, and mulberry leaf ethanol extract was given Rats induced by HFD/STZ (200 mg/kg/day)

Method Results The analysis of the intestinal flora showed that the ethanol extract of mulberry leaf can partially restore the intestinal flora to a normal state

In summary, mulberry leaf has been widely used as a traditional medicine for long-term treatment of type 2 diabetes in Asia
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Previous research supports its role in lowering blood sugar levels and regulating the intestinal microbiota

Mulberry traditional medicines in Asia, has been widely used as a long-term treatment of type 2 diabetes study confirms that mulberry leaf ethanol extract (MLE) can improve the intestinal microflora disorders in diabetic rats and enhances glycogen brittle help further Discover new therapeutic targets with the help of research

Original: Liu ZZ, Liu QH, Liu Z, et al.

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