BMC Med: Sad... BMJ sub-journal reveals: obesity causes cancer, men and women are different!

It is well known that the disease comes from the mouth: people who can't control their mouths and can't open their legs are mostly obese players, and obesity increases the risk of a variety of cancers represented by colorectal cancer.
, a 2020 edition of the White Paper on Colorectal Cancer and Pre-cancer Lesions in China's Medical Examiner's Population, based on molecular diagnosis, was released.
the White Paper provides a more comprehensive reflection of the state of the nation's gut health.
the number of positives in 75,229 samples was 6,776, or 9.01 percent, a slight increase from 8.93 percent in 2019.
the gender distribution, men's intestinal health problems are more serious, which may be related to men's irregular lifestyle and high frequency of smoking and drinking.
positive rate, the intestinal health of Chinese people also shows a certain geographical distribution characteristics.
results show that the positive rate in the south is higher than that in the north, and the positive rate in the west is higher, followed by the eastern, northeast and central regions.
let's look at other related studies.
study, published today in BMC Medicine, a team led by the University of Bristol and the International Agency for Research on Cancer looked at the effects of different body fat measurements on colorectal cancer risk in men and women.
a large study of more than 100,000 people found that a higher body mass index (BMI) was more risky for men, while a higher waist-to-hip ratio (waist divided by hips to measure abdominal fat) was more risky for women.
the new study, researchers analyzed the sex and body-specific association between obesity and colorectal cancer risk, and whether obesity-related metabolites could explain the association between obesity and colorectal cancer.
the genetic variation of 123 metabolites, including BMI, waist-to-hip ratio and targeted metabolomics, the researchers used Mendel randomization to study the gender combination and gender specificity of BMI and lumbar-to-leg ratios at risk of colorectal cancer.
study was based on data from 58,221 patients enrolled in the Colorectal Cancer Genetics and Epidemiology Alliance, the Interdisciplinary Study of Colorectal Cancer, and 67,694 control group participants.
study showed that for every 4.2 kg/m2 increase in BMI in men, the risk of colorectal cancer increased by 23%, and in women, the risk of colon cancer increased by 9% for every 5.2 kg/m2 increase in BMI.
0.07 per cent increase in the waist-to-hip ratio increases a woman's risk of cancer by 25 percent, compared with a 5 percent increase for men.
study showed that higher BMI significantly increased the risk of colorectal cancer in men, while higher waist and hip circumference significantly increased the risk of colorectal cancer in women.
obesity is associated with many metabolic changes, but these do not explain the relationship between obesity and colorectal cancer.
need more detailed metabolomic studies to clarify their mechanisms.
According to the World Health Organization/International Agency for Research on Cancer Global Cancer Report 2020, colorectal cancer is the third most common cancer in the world, but it is one of the most preventable cancers that can be achieved through a balanced diet, increased exercise and maintaining a healthy weight.
Dr Emma Vincent, co-author of the study and in the MRC Department of Integrated Epidemiology at the University of Bristol, said: "Our study is the largest study of the difference between fat and bowel cancer risk in men and women, highlighting the need for a more nuanced approach to cancer prevention.
are now working on a clear understanding of how increased body fat causes colorectal cancer, which could lead to new targets for reducing the risk of cancer.
important because maintaining weight is very difficult for many people.
Diaz Font, director of the World Cancer Research Foundation (WCRF), added: "We know that being overweight or obese increases the risk of at least 12 types of cancer, including colorectal cancer.
but this new study further underlines the importance of involving a wider population in the study, as we do not yet fully understand the role that gender or race may play in cancer risk.
natasha Paton, health information manager at Cancer Research UK, explains: "It is well known that unhealthy weights pose a risk of many types of cancer.
most studies on obesity and cancer use BMI, but the study adds new evidence that excess waist fat also has an effect.
people can reduce their risk of colorectal cancer by maintaining a healthy weight, eating more fiber, eating less red and processed meat, drinking less alcohol and not smoking.
, early diagnosis of bowel cancer can also save lives.
so if you notice any unusual changes, seek medical attention in a timely manner.
encourage people to have regular bowel cancer screening.
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