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    Home > Active Ingredient News > Antitumor Therapy > BMC Med: Apatinib + Oxaliplatin + Capecitabine Neoadjuvant Therapy for Locally Advanced Gastric Cancer/Gastroesophageal Junction Cancer

    BMC Med: Apatinib + Oxaliplatin + Capecitabine Neoadjuvant Therapy for Locally Advanced Gastric Cancer/Gastroesophageal Junction Cancer

    • Last Update: 2022-05-25
    • Source: Internet
    • Author: User
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    Gastric cancer is one of the most common and deadly cancers in China


    stomach cancer

    Patients with advanced gastric cancer are often treated with drugs


    Blood vessel

    This study is a single-center, single-arm Phase 2 clinical trial conducted in Shanghai Fudan Zhongshan Hospital, recruiting patients with locally advanced (cT3/4aN+M0) gastric or gastroesophageal junction (GEJ) adenocarcinoma for three courses of treatment of oxaliplatin (135 mg/m2, D1), capecitabine (1000 mg/m2, 2/day, D1-14) and apatinib (250 mg/day, double the dose for the third cycle) Treatment, plus a course of oxaliplatin and capecitabine, followed by gastrectomy + D2 lymphadenectomy




    Screening objective response rate was 78.



    hypertension

    In conclusion, the combination regimen of apatinib, oxaliplatin, and capecitabine as neoadjuvant therapy for locally advanced gastric/gastroesophageal junction adenocarcinoma showed reliable efficacy and controllable safety, and it is worth developing 3 Phase clinical trials for further validation


    The combination regimen of apatinib, oxaliplatin and capecitabine as neoadjuvant therapy for locally advanced gastric/gastroesophageal junction adenocarcinoma showed reliable efficacy and controllable safety .


    Tang Zhaoqing,Wang Yan,Yu Yiyi et al.




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