Blood: VEGF-C protects the integrity of the micro-environment around bone marrow blood vessels.

Central point: The absence of Vegfc in endothelectric cells or LepR-plus cells affects the maintenance of micro-environments around bone marrow blood vessels and hematopoietic stem cells;
summary: Hematopoietic stem cells (HSCs) reside in bone marrow (BM) stem cell niches, where HSC regulates important sources of signals.
and chemotherapy can damage the micro-environment of HSC, including its sinus-like blood vessels and vascular cells, leading to a slow recovery of hematosis.
, identifying factors that protect the HSC micro-environment in injury can provide important therapeutic opportunities to improve hematocyte regeneration.
recently, a study published in the journal Blood revealed the key functions of vascular enditer growth factor C (VEGF-C) in maintaining the integrity of the micro-environment around BM blood vessels and improving the recovery of BM micro-environments after radiation-induced injury.
(Vegfc's level of expression in different cells) can cause damage to the micro-environment around BM blood vessels by knocking out or conditional knocking out endothelectocytes or Leptin-positive (LepR-plus) cells.
, Vegfc in depleted microencellular environments can delay post-transplant hematosis by reducing endothelectal cell proliferation and LepR-plus cell regeneration.
(knocking out Vegfc's effects on the recovery of different blood cells after transplantation) veGF-C via adenovirus vector exgengencies can promote post-radiation hematosis recovery by accelerating the regeneration of endothelocells and LepR-plus cells and increasing the expression of hematogenespheric regeneration factors.
, the study shows that preserving the integrity of the micro-environment around blood vessels through VEGF-C signals may be an effective treatment to enhance hema production regeneration.
.