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Gastrointestinal (GI) graft anti-host disease (GvHD) is a major obstacle to hematopoietic stem cell transplantation (AHST).
metabolite visoric acid (RA) enhances GI-GvHD in mice by expressing the same reactive T cells of ra-subject alpha (RAR alpha), but the role of RA-reactive cells in human GI-GvHD is unclear.
In this study, Ball and others used traditional and new sequential immune staining and fluid cytometry to carefully observe RA-reactive T-cells in AHST patients' tissues and blood, and to characterization of the effects of RA on the heterogeneic response of human T-cells.
(an increase in the number of RAR alphahi monocytes in GI-GvHD tissue) increased the expression level of RAR alpha in a single human nuclear cell after RA exposure.
in GI-GvHD tissue, the number of RAR alphahi monocytes increased, and the RA binding proteins in these cells increased, located where tissue damage was located, associated with the severity and death rate of GvHD.
(increased expression of T-bet in GvHD tissue) by targeting candidate proteins, the researchers predicted the esopratin of RA reactive T cells in the case of an increase in micro-environment IL-23.
sequential immune staining confirmed the presence of a group of RARahi CD8T cells with predictive esoteric forms, co-expression effect T-cell transcription factors T-bet and IL-23 specific subjects.
these cells increased in GI-GvHD tissue, but not in skin-GvHD tissue, and were selectively amplified in the blood of GI-GvHD patients.
, functional studies have shown that RA mainly increases the iso-reactive RARahi CD8 effect T cells, including esoplical cells identified in the body.
conditions rich in IL-23 can be enhanced by selectively increasing the expression of b7 integratives on CD8-effect T-cells and reducing CD4 T-cells with regulated cell estypes.
, Ball and others identified a unique set of RA reactive effect T cells that selectively amplification in human GI-GvHD as potential new therapeutic targets.
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