Blood tests monitor the death of myocardial cells

scientists
a non-invasive way to detect the death of myocardial cells, according to a medical paper published today. By measuring circulating free DNA released by dying myocardial cells, cardiomyopathy associated with cell death, such as myocardial infarction (heart disease) and sepsis, can be diagnosed and monitored in a highly sensitive and specific manner.
The original power of human blood circulation comes from the contraction and lysosis of the heart, but various pathogenic factors, such as infection, element deficiency, poisoning, severe persistent ischemia, etc. can directly cause the death of myocardial cells, which in turn causes the contraction of the heart muscle disorder, which eventually leads to morbidity. Among them, myocardial infarction is an acute coronary artery, persistent isotrophic hypoxia caused by myocardial necrosis, the survey shows that about 1.5 million people in the United States every year myocardial infarction, Asian countries in recent years also showed a clear upward trend;
this time, a team of scientists at the Hadassah School of Medicine at the University of Hebrew in Israel discovered a methylation marker in the DNA of human heart muscle cells and developed a way to detect it in the blood.
study confirmed that the method is highly sensitive and specific and can be diagnosed in patients with heart disease, with effects similar to those used to detect tcalledcalin levels in the blood - the current gold standard for clinical testing of heart tissue damage. In the plasma of patients with sepsis, the level of heart-specific free DNA markers increased significantly, indicating the mass death of myocardial cells in the patient's body. This newly discovered marker is more indicative of short-term mortality from sepsis than trinin.
researchers say that while the link between circulating free DNA and cell death needs to be fully demonstrated, scientists believe the new method could complement known biomarkers of heart damage and hopefully help clinicians distinguish between cardiomyocyte death and reversible cell damage. (Source: Science and Technology Daily Zhang Mengran)