Blood-sinking and tonic, SLE activity weather vane! Health Science

Systemic lupus (SLE) is a chronic autoimmune disease with multi-system damage, the exact etiology is unknown, can affect the skin, pulp membrane, joints, kidneys and central nervous system, etc., the pathological manifestation sonofing of autoantibodies and immunocompoundsin the SLE laboratory inspection project, blood sink and complement is two common indicators of SLE, but also two indicators of ups and downs, today to take you together to understand what clinical significance of blood sinks and complements, they are for SLE patients what clinical reference value!blood sinkblood sink semorrhage rate (ESR) refers to the rate at which red blood cells naturally sink in the whole blood of the exclusive anticoagulant under the prescribed conditions, and is an indirect test to measure the degree of inflammation in the bodythe test actually measures the rate at which red blood cells decline in blood samples placed in high, thin vertical tubesESR is a nonspecific indicator that affects ESR by a number of factors such as red blood cell count, red blood cell shape, red blood cell aggregation status, increased levels of acute stage reactants in the blood (e.gC reactive protein (CRP) and fibrinogen), immune complex, macroglobulin and visceral substantial damageabout 90% of active SLE patients will increase rapidly, and with the improvement and deterioration of the disease and slow down or increase faster, but according to the study that SLE patients even if the disease is controlled, its ESR can still be higher than normal, so ESR can not be used as an indicator to judge the return of SLE disease, can only be used as a non-specific indicator to observe the change of the diseasetonictonic (complement, C) system includes more than 30 components, widely found in serum, tissue fluid and cell membrane surface, is a protein response system with precision regulation mechanism, but also participate in the inherent immune response of important immune effect moleculesdeficiencies in the function of the complement system, including the absence of components or dysfunction of function, can damage the tissueactivate the complement system is the first step to prevent damage to immunocompoundsThe mechanism of SLE tissue damage may be caused by immune complex-type allergic reactions, in which type II and type III perversions are enhanced, which can lead to increased supplementary consumptionin the Laboratory inspection project of SLE, the examination of the complement is commonly used in the total complement (CH50), C3, C4 testif the complement is low, especially if C3 is low, it is often suggested that there is SLE activityIn addition to indicating SLE activity, C4 low may still be a manifestation of SLE susceptibility (C4 deficiency)C4 is the second activated tonic molecule in the classic pathway, which also reflects the change of the condition of SLE patients to some extent, and its level change can be used as an important indicator of sLE disease activityC3 is a key component of the classical activation and replacement activation pathway process of the complement systemEarly studies have found that lower complement levels are not always associated with SLE activity, but that the decrease in complements is associated with SLE and kidney and blood systemstherefore, it can be considered that serum complement C3 reduction is closely related to SLE, may be due to complement activation caused by C3 consumption, or SLE damage to the liver caused by C3 synthesis deficiencyDamage caused by SLE is caused by immune complex mediated and activated tonicswhen the complement is activated and gradually degraded by traditional or bypass routes, its content will also be reduced, so when the content of the tonic in the blood is reduced, the body is in the injury stage, that is, the SLE activity periodand a study observed that c3 and C4 levels decreased simultaneously during SLE activity, but c4 levels decreased significantlyThe decrease of C4 often predates C3 and other tonic components, while the recovery is later than other tonic componentsIn most cases of SLE, serum supplement reduction is associated with the worsening of the diseaseIf the complement content returns to normal, the body is relatively stableso, according to the above explanation for SLE patients blood sink and complement examination, we can clearly C3, C4 in SLE disease is sensitive specific indicators, but ESR can only be used as a reference index, only the combination of the two, in order to more accurately judge the disease in a timely manner to take appropriate treatment measuressource:sleains