Blood: Short telomere length predicts non-recurrence mortality after stem cell transplantation in MDS patients

Heterogenetic hematopoietic stem cell transplantation is the only potentially curable treatment for bone marrow growth syndrome (MDS), but the risk of transplant-related complications limits the patient's long-term survival prognosis.
length of short telomeres mediated by genetic or access factors affects the cell's response to genotoxicity and replication stress, and identifies patients at higher risk of toxicity after transplantation.
Mykko et al. tested the relative telomere length in blood samples of 1,514 MDS patients prior to transplantation and assessed the correlation between telomere length and MDS disease characteristics and transplant prognostics. analysis of the correlation between
telomere length and age, somatic cell mutations found that shorter telomere lengths were significantly associated with older, male, somatic cell mutations that affect DNA damage response, and more severe cell reduction before transplantation, but were not related to marrow maternal cell count, MDS therapy history, or past cancer treatment history.
The prognostication of patients with different telomere lengths was significantly corrected for clinical and abnormal variation, and the four-ways with the shortest telomere length were significantly associated with poor survival rates in 1,267 patients aged ≥40 years, a result attributed to a higher risk of recurrence-free mortality (NRM) in such patients.
the adverse effects of shorter telomeres on NRM were independent of the merger in transplant patients, and were occasionally seen in patients receiving greater intensity pre-treatment, including myelin and higher doses of mephedrone-based intensity reduction programmes.
Severe acute GVHD prognosis in patients aged
40 years and older In patients with severe acute graft anti-host disease, shorter telomeres can significantly affect NRM, suggesting that shorter telomere lengths may limit the regeneration potential of mucous membrane tissue after acute injury.
In summary, patients with MDS with shorter telomere lengths may consider taking appropriate measures to minimize the toxicity of transplantation due to the low survival rate due to high toxicity, thereby improving the survival prognostication of such patients.
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