Blood: RET activation improves survival and amplification of hematopoietic stem cells
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Last Update: 2020-07-13
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Source: Internet
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Author: User
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Artificial bloodstem cell(HSC) in vitro culture amplification is a rapidly developing field, showing great hope for clinical applicationRecent studies have shown that the nervous system and glial familial ligand (GFL) are the potential drivers of hematopoietic survival and self-renewal in bone marrow niches, but how to apply it to the maintenance and amplification of HSC remains to be exploredGrey et alrevealed the role of GFL receptor RET on the surface of HSCs cells in medialing on sustained cell growth, resistance to stress, and improved cell survival throughout the entire in vitro amplification processtreatment of HSCs with THE RET ligand/coreceptor complex GDNF/GFRa1 improves progenitor cell function at the initial transplant and the long-term function of HSC during secondary transplantationfinally, the researchers confirmed that RET drives multiple intracellular signaling pathways, including key signal ingons AKT, ERK1/2, NF-B, and p53, responsible for a wide range of cellular and genetic responses, thereby improving the growth and survival of in vitro cultured cells
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