Blood: Quantitative proteomics reveals the unique metabolic characteristics of AML stem cells
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Last Update: 2020-07-13
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Source: Internet
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Author: User
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Acute myeloid leukemia (AML) is characterized by the accumulation of cloned myelin cells that cannot differentiate into mature white blood cellsChemotherapy can relieve most patients, but the recurrence rate is high and leads to poor clinical prognosisThis is mainly caused by chemotherapy-resistant leukemiastem cell(LSC), so LSC must be eradicated to improve patient survivalhave previously studied LSC mainly at transcription levels, there is a lack of information on post-transcription regulatory genes and related networksRaffel et alextended previous reports of LSC proteomics to healthy age-matched hematopoietic stem cells and progenitor cells (HSCs) and associated proteomics with corresponding transcription groupsby comparing LSC with leukemia mother cells and healthy HSPC, Raffel et alvalidated LSC candidate markers and highlighted new, potentially targeted proteins that are not present or rarely expressed in HSPCin addition, the study data provide strong evidence that LSC has unique energy metabolism, adhesion molecular composition, and RNA processing characteristicsThe association of proteomics and transcription data from samples of the same individual also highlights the importance of proteomic analysis, which is particularly effective in detecting changes in metabolic pathwaysin general, the study provides a comprehensive set of proteomics and transcriptions for functionally validated LSC, mother cells, and healthy HSPs, and helps develop LSC-oriented therapies
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