Blood: Pym single antisequential AVD chemotherapy is effective in treating classic Hodgkin's lymphoma.

Pembrolizumab is a humanized IgG4 monoclonal antibody for the programmed death-1 protein that has been shown to be effective against recurring/refractic classic Hodgkin's lymphoma (cHL).
In order to assess the rate and safety of fully metabolic remission (CMR) of the newly diagnosed cHL of Pym monoantigen therapy, Allen and others conducted a multi-center, single-arm, Phase II Pymdamantamycin, Changchun neo-alkali, and dacabatin (AVD) pre-chemotherapy trial.
recruit patients ≥ 18 years of age, early untreated, disadvantaged or terminally ill.
the proportion of patients who received remission at different nodes was included in 30 patients with early adverse (n-12) or late-stage (n-18) cHL patients who received 3 cycles of Pym monoantigen therapy, followed by 4 to 6 cycles of AVD therapy according to phase and volume.
12 cases of large vertical lumps and/or larger lumps .
After Pym monotherapy, 11 patients (37%) developed CMR, and 7 (25%) of the 28 patients who received a positive electron emission fault scan/computer fault scan (PET-CT) had a metabolic tumor volume reduction of more than 90%.
two patients with large lumps received CMR after two AVD cycles and maintained their remission at the end of treatment with tumor volume changes (A→B, C→D) after three courses of Pym monotherapy.
22.5 months (range: 14.2-30.6 months) with no change in treatment, progress or death.
no patients received consolidated radiotherapy, including those with large-headed diseases.
treatment is well-to-do.
immune-related adverse events were a grade 1 rash (6 cases) and a stage 2 infusion reaction (4 cases).
patient had an elevated reversible level 4 transaminase and another had reversible Bell's palsy (facial nerve paralysis).
, transient Pym monotherapy and AVD therapy have been shown to be effective and safe in newly diagnosed cHL patients, including patients with large lumps.
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