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Blood: New sub-type - tissue resident memory B cells.

 Last Update: 2020-09-01
 Source: Internet
 Author: User

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Although human B cells have been widely studied, most of the reports have been carried out using outer blood as the source of B cells.
the study, Weisel et al. used a unique tissue source, taken from the tissue of a healthy organ donor, to study the human B-cell chambers of different organs of different donors.
results found that B cells in the outer blood were unbalanced from the regions of other tissues.
the frequency and type of CD27 plus memory B cells (MBC) were significantly different from cd27 to memory B cells (MBC).
a comprehensive Ab-based screening found biomarkers for MBC, which identified new MBC substations that were different from the substations of surface expression CD69 and CD45RB.
addition, the researchers defined a tissue-resident MBC dedict that is dominant in the intestine but does not exist in the blood.
RNA sequencing of MBC substates in a variety of tissues revealed the genetic characteristics of tissue-resident MBC and intestinal and spleen-specific.
, the study provides new insights into the functional characteristics of human B-cell chambers in multiple tissues.
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