Blood: Lysine-specific demethylatase 1A (LSD1) limits in vitro amplification of human HSC and is a target for UM171
-
Last Update: 2020-07-12
-
Source: Internet
-
Author: User
Search more information of high quality chemicals, good prices and reliable suppliers, visit
www.echemi.com
At present, hematopoieticstem cellstransplantation is still the only cure for a variety of malignant blood diseases, but has been limited by the lack of cell donors, high-quality cells can not fully proliferate and other issuesAs a result, researchers have long been working to explore the conditions under which hematopoietic stem cells can be amplified for use in clinical practicerecently published an article in the journal Blood, Subramaniam et alfound that inhibiting epigenetic regulatory factor lysine-specific histone demethylase 1A (LSD1) can induce rapid amplification of CD34-plus cells from human cord blood sources and promote long-term in vitro reproduction of HSC by preventing differentiationthe phenotype and molecular properties of cells treated with LSD1 inhibitors are highly similar to those of cells treated with UM171, a reagent that promotes HSC amplification through unknown mechanisms and are currently being tested in clinical trialsThe researchers found that LSD1 and other LSD1 members containing the chromatin remodeling complex CoREST rapidly prophenotized after UM171 treatmentknocking out The core member of CoREST RCOR1 through CRISPR/Cas9 can lead to CD34 plus cell amplification, similar to LSD1 inhibition and UM171 treatmentin general, LSD1 and CoREST can limit the amplification of HSC, is the main target of UM171, providing a theoretical basis for UM171's HSC to promote activity
This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only.
This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of
the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed
description of the concern or complaint, to
service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content
will be removed immediately.
