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Central point: In B-cell lymphoma, impaired function of NK cells is associated with lipid build-up.
NK cells enhance lipid metabolism to suit lipid-rich cancer environments.
: NK cells have an important protective effect in blood malignancies, but NK cells can obtain a dysfunctional state in which their anti-tumor immune activity is limited.
, the underlying cause of this impaired function of NK cells remains unclear.
A new study published recently in the journal Blood by Kobayashi et al. found that NK cells underwent extensive transcriptional reprogramming in invasive B-cell lymphoma, accompanied by lipid metabolism enhancement, including elevated expression levels of the transcription regulator PPAR-g.
fatty acids exposed to lymphoma significantly inhibit NK cell effect response and cell metabolism.
ifN-g yield of NK cells isolated from patients with diffuse large B-cell lymphoma and mice with E-myc-B-cell lymphoma were reduced.
activates the PPAR-g part to restore the membrane likeestion of the mitochondrial and the production of IFN-g.
, this study shows that enhancing lipid metabolism while impairing its function is the functional adaptation of NK cells to fatty acid-rich lymphoma environments.
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