Blood: Immune synaptic components HLA-II and CD58 Activate Rose Knot T Cells

Note: T-cell rose knot, is the name of sheep red cell (SRBC) combined with a rose knot on the surface of T cellsT cells bind to SRBC because the cell surface has a class of receptors that bind to SRBC surface glycopeptides - E receptorsa unique feature of Hodgkin'slymphoma(HL) is the protection and promotion of tumor cell survival around the tumor cells around CD4 plus T cellsThe adhesion molecules involved in this so-called T-cell rose knot are an important part of theimmunitysynapses (IS)however, it is not clear whether the synapse is fully assembled, causing T-cell activation by interacting with the T-cell receptor (TCR) with the human type II leukocyte antigen (HLA-II)recently, Veldman et alhave created a new model of rose knots by co-cultured HLA-II matching PBMCs and HL cell lines, and demonstrated the formation of IS by activating rose knot T cellsThe reduction of HLA-II through CIITA does not affect the degree of rose knot, but the activation of T cells is almost completely abolishedinterestingly, the level of expression of CD58 is related to the degree to which rose knots are formed, and knocking out CD58 or blocking CD2 reduces the formation of rose knots and T-cell activationextended the findings to primary HL tissue through immunohisciting and adjacent ligation analysis, and the results showed that CD2 interacted with CD58 and TCR-related CD4 interacted with HLA-IIIn short, in HL, T-cell rose knots are established by the formation of IS, and the key to the activation of rose knotST cells depends on the interaction of TCR-HLA-II and CD2-CD58