Blood flow affects tumor cell metastasis

have long believed that blood flow plays an important role in cancer metastasis. However, studies that have tested this hypothesis in zebrafish and humans have confirmed that circulating blood flow affects the position of tumor cells in the vein system that stagnates and excretes the body, where they can form metastasis.
In a paper published recently in
, researchers at France's National Institute of Health and Medical Research (INSERM) found that in zebrafish embryo models, people can track labeled circulating tumor cells (TC) throughout their vein systems, and that areas where tumor cells stagnate are closely related to blood flow speeds below 400 to 600 m/s.
long-term view in this area is that CTC stays in tiny capillaries due to size limitations. "This study shows that this location is not only physiologically limited, but that blood flow has an important effect on the adhesion of tumor cells to the formation of blood vessel walls, which I think is an important complement to understanding how and where tumor cells metasmot," said author Jacky G. Goetz. The
chose the zebrafish embryo model because its blood vessels were highly consistent. This makes it easier to record the location of tumor cells after injection. Goetz explains. The team put all the images together to create a map of the location of tumor cells in the vein system.
also found that blood flow is critical to the exopeditation process when tumor cells leave circulating blood vessels and form secondary tumors through the endothial barrier in new locations. "When we did time-lapse imaging in zebrafish embryos, we found that endothel cells seemed to curl around tumor cells caught in blood vessels. " "At this point, blood flow is essential, and without it, endoskin remodeling doesn't happen," Goetz said. This requires a certain amount of blood flow to keep endothelled cells active so that they can be remodeled around tumor cells. After
, they used live imaging to observe the brain metastasis of tumors in mice, and finally confirmed this conclusion. The researchers then used the findings to study brain metastasis tumors in 100 patients with different primary tumor locations and to map the location and heat of the metastasis. Goetz et al. combined the brain metastasis tumor map with the perfusion map of the controlled patient and found that it reproduced the conclusions of its zebrafish experiment well.
all of these findings suggest that blood flow at the metastasis site regulates where and how metastasis growth occurs in tumor cells, the researchers concluded. The researchers also plan to study ways to inhibit the ability to reshape the endothor skin of blood vessels, potentially reducing CTC osmillating and inhibiting metastasis. (Source: Science Network Tang One Dust)