Blood: fetal liver ferrite regulation fetal iron reserves in late pregnancy
-
Last Update: 2020-07-12
-
Source: Internet
-
Author: User
Search more information of high quality chemicals, good prices and reliable suppliers, visit
www.echemi.com
In adults, the liver-derived hormone ferritin (HAMP) regulates the overall iron level of the body by blocking the ferrite-exporting protein transferrin (FPN), iron absorption and reabsorption sites in the intestines and spleen, respectivelyImpaired HAMP expression or FPN's abnormal response to HAMP can cause iron overloadHAMP is also expressed in the fetal liver, but its role in regulating fetal iron storage is not yet knownTo address the role of HAMP in regulating fetal iron storage without being influenced by the mixed factors of maternal iron steady state changes, the researchers established fetal mice that carried the hamP resistance fpnC326Y gene that carried the parent's geneticsIn addition, in order to avoid any confounding factors of changes in the stable state of the placenta iron, the researchers established a fetal rat with fpnC326Y liver-specific knock-in or hamp gene knockoutresults showed that these fetuses had reduced liver iron reserves and hemoglobin, and a significant increase in FPN in the liver, but normal in the placentaAs a result, the researchers speculated that hamP in fetal mice's liver could operate autonomously in cells to increase iron storage in the fetal liverthe results of this study also show that, under normal physiological conditions, FPN in the placenta is not actively regulated by fetal liver HAMP
This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only.
This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of
the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed
description of the concern or complaint, to
service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content
will be removed immediately.
