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Ineffective plate platet infusions can lead to poor prognosis and increased medical costs.
treatment of the incurable nature caused by HLA iso-immunity requires the use of HLA antigen-matched plateplates, but requires a large number of plateplate donors and is not guaranteed to match exactly.
the study was a randomized, double-blind, non-disadvantaged, cross-test designed to compare the prognosis of plateplates infused with HLA table matching (HEM) and plateplates with HLA standard antigen matching (HSM).
HLA antibody specificity and target physiometer identification included in the standard: manifestations of isoimmune, plate plate plate refraction, plate plate plate reduction of regenerative anemia, bone marrow growth abnormal syndrome or acute myeloid leukemia patients.
use HLAMatchMaker table matching (especially small fragments) to select HEM plateplates.
patients receive up to 8 randomly sequential preventive HEM and HSM infusions.
result is an increment of plate plate count (PCI) 1 hour after blood transfusion.
49 patients from 14 hospitals in the UK were randomly grouped.
in intentional therapy, heM and HSM had 107 and 112 assessable blood transfusions, respectively.
average PCI (SD) of HEM and HSM was 23.9 (15) and 23.5 (14.1), respectively.
HEM was declared non-inferior to HSM because the lower limit of the 95% confidence interval was not greater than the predetermined non-inferiority limit.
the secondary results of hemorrhage misalmissing one hour PCI affecting plate plate count, blood transfusion requirements, and bleeding events.
when there are an average of 3.2 table misaleds, plateplate count increments of less than 1 hour after plateplate infusion can be comparable to plateplate count increments of 1 hour after plateast infusion when 5.5 tableboard misal palettes are misalfused.
addition of a misalmissed table, the likelihood of an appropriate increase in platette count was reduced by 15%.
therefore, HLA isoimmune patients should as far as possible infusion of table antigen-matched plateplates.
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