Blood: Early diagnosis of heparin-induced plate plate plate reduction!

Heparin-induced plateroid reduction (HIT) is a life-threatening, thrombosis-induced, antibody-mediated disease.
in order to maximize the likelihood of rehabilitation, early and accurate diagnosis is essential.
widely used HIT tests, such as plateboard factor 4-heparin ELISA, lack specificity and are considered the "gold standard" for C14-labeled serotonin release trials (SRA) because they are only available through reference laboratories and have limited application value in early patient management.
recent studies have shown that "pathogenic" HIT antibodies selectively activate plateplates treated with PF4, while a technically simpler method of detection, P-selective expression analysis (PEA), on which PF4 depends, may provide a fast and accurate detection.
(Research Process) classified 409 adults suspected of HIT as disease-positive, negative, or uncertain based on predefined criteria combined with 4Ts scoring and HIT ELISA results.
classified as "HIT-uncertain" were considered disease-negative in the initial analysis and positive in the sensitivity analysis.
(sensitivity and specificity of PEA and SRA) compared the ability of PEA and SRA to diagnose HIT patients using subject operating characteristic curve statistics.
these predefined criteria, the DIAGNOSTIC accuracy of the PEA is high (the sub-curve area (AUC) is 0.94; 95% CI 0.87 to 1.0), similar to the SRA (0.91; 0.82 to 1.0).
sensitivity analysis, PEA and SRA's AUC were similar, at 0.88 (0.78 to 0.98) and 0.86 (0.77 to 0.96), respectively.
, PEA is a technically simple non-radioactive detection method that uses about 20 times less plateplates than SRA and is highly accurate in the diagnosis of HIT.
widespread use of PEA may help to deal with suspected HIT patients in a timely and effective manner.
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