Blood: BET inhibitor CPI203 promotes umbilical cord blood HSC and macrophage amplification
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Last Update: 2020-07-13
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Source: Internet
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Author: User
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Although cytokine-mediated artificial bloodstem cell(HSCs) amplification can lead to high production of hematopoietic progenitor cells, this is usually at the expense of reducing the regenerative capacity of bone marrow hematopoietic stem cells, thus limiting the potential therapeutic application valueGiven that the brominated domain of protein (BCPs) has been shown to regulate the self-renewal and resting state of HSC in mice, Peng Hua et alscreened small molecules targeting various BCPs as potential reagents for in vitro amplification of artificial blood stem cellsof the 10 tested compounds, only the bromine domain and BET (Extra-terminal) inhibitor CPI203 can enhance human umbilical cord blood HSC in vitro amplification, without loss of cellular vitalityIn a series of transplant trials, amplification cells have also been shown to improve transplantation and regenerationtranscription groups and functional studies show that the amplification of long-term regenerative HSC is accompanied by the simultaneous amplification and maturation of macronuclear cells, consistent with the reprogramming of the CPI203-mediated umbilical hematopoietic stem/progenitor cells (HSPCs)in general, this method may help in vitro gene editing, enhance platelet production, and improve the use of cord blood in transplant studies and treatments
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