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    Home > Active Ingredient News > Blood System > Blood: Bentuximab combined with nivolumab to rescue the long-term prognosis of relapsed/refractory Hodgkin's lymphoma

    Blood: Bentuximab combined with nivolumab to rescue the long-term prognosis of relapsed/refractory Hodgkin's lymphoma

    • Last Update: 2021-08-26
    • Source: Internet
    • Author: User
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    About 10%-30% of patients with classic Hodgkin lymphoma (cHL) are refractory to initial treatment or relapse after standard treatment


    Lymphoma stem cells

    Phase 1-2 studies evaluated the combination of Bentuximab (BV) and Nivolumab (Nivo) as the primary rescue therapy for patients with relapsed/refractory (r/r) classic Hodgkin lymphoma (cHL) Effectiveness and safety


    In the first and second parts, BV and Nivo are staggered in the first cycle, and BV and Nivo are given on the same day in the 2-4 cycle


    PFS and OS

    PFS and OS

    The objective response rate (ORR; n=91) was 85%, and 67% of patients achieved complete remission (CR)


    The objective response rate (ORR; n=91) was 85%, of which 67% of patients achieved complete remission (CR), and the objective response rate (ORR; n=91) was 85%, of which 67% of patients achieved complete remission ( At a median follow-up of 34.


    immunity

    The results of the study showed that the long-term follow-up of BV and Nivo as the primary rescue program showed long-lasting efficacy and excellent progression-free survival (PFS), especially in patients who underwent transplantation directly after the end of the study treatment, and there was no additional Toxic reaction


    The long-term follow-up of BV and Nivo as the primary rescue plan showed long-lasting efficacy and excellent progression-free survival (PFS), especially in patients who underwent transplantation directly after the end of the study treatment, and there was no additional toxicity.


    Original source:

    Ranjana H.


    Brentuximab vedotin in combination with nivolumab in relapsed or refractory Hodgkin lymphoma: 3-year study results

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