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Blood: Arginine synthesis "buff" enhances the proliferation and anti-tumor efficacy of CAR-T cells

 Last Update: 2020-07-12
 Source: Internet
 Author: User

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Blood and solid tumors break down the metabolism of the semi-essential amino acid arginine to drive cell proliferation, resulting in lower arginine levels in the tumor microenvironmentThe low arginine microenvironment then impairs the proliferation of cells of chimeric antigen receptor T cells (
CAR-T), limiting their efficacy in clinical trials for hematology and solid malignanciesT cells are susceptible to arginine microenvironmentdue due to the low expression of arginine resynthetic enzyme seine sasse (ASS) and eunine transaminase (OTC) in T cellsFultang et alhave found that T cells can be reprogrammed to express functional ASS or OTC enzymes, in synergy with different chimeric antigen receptorsenzyme modification increases CAR-T cell proliferation without affecting cytotoxicity or fatigue of CAR cellsIn the body, enzyme-modified CAR-T cells can increase the removal rate of leukemia or solid tumor load, this study is the first to show a therapy for metabolic modification to enhance the efficacy of CAR-T cells

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