Blood: Acute GVHD can be prevented with IRX4204-targeted vending acid nuclei.

Nuclear receptors (NRs) and remembr acid X receptors (RXRs) act as immunomodulation through ogenosomes and heterogeneity disorganized bodies with multiple nuclear receptors, including revant acid receptors, to control inflammation and metabolism.
IRX4204 is a new, highly specific RXR astrogen that can effectively and selectively activate RXR iso-djusts in clinical trials, but does not activate iso-2000s.
(Survival of mice treated differently after transplantation) Thangavelu and others found that IRX4204 was better at preventing acute graft anti-host disease (GVHD) in vivo than FK506 (tekmos, used to prevent transplant rejection after liver and kidney transplantation);
IRX4204 after transplantation can reduce intestinal damage and reduce serum interferon-gamma and tumor necrosis factor-alpha levels.
transcription analysis of the supply T cells isolated in the intestines of transplant-resistant host disease mice treated with IRX4204 showed a significant reduction in transcription of regulated inflammatory pathogenes.
in vitro, IRX4204 promotes the induction of differentiation from the original CD4-T cells to the Treg cells, and in vivo, IRX4204 promotes the conversion of the supply Foxp3-T cells in GVHD mice to the extrinsic blood Foxp3-Tregs cells.
(tumors in transplanted mice with different treatments) used Foxp3 genealogy tracer mice that track the origin of Tregs cells and current FoxP3 expressions, the researchers demonstrated that IRX4204 promotes the stability of Treg cells.
, although Thergs differentiation of transplant recipients treated with IRX4204 increased and Th1 differentiation decreased, the anti-leukemia response to transplants of leukemia and lymphoma cells was maintained.
, it is important to note that IRX4204 can reduce the proliferation of human T cells and promote the production of Treg cells in in-body mixed lymphocyte response culture.
, the above results show that targeting RXRs with IRX4204 can be used as a new method to prevent acute GVHD clinically.
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