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Center point:
Center point:Patients with sepsis present with acquired platelet function defects and massive loss of GPVI receptor reactivity
Patients with sepsis present with acquired platelet function defects and massive loss of GPVI receptor reactivityPlatelet GPVI dysfunction is already obvious in the early stage of the disease and will recover after the patient recovers
Platelet GPVI dysfunction is already obvious in the early stage of the disease and will recover after the patient recoversGlycoprotein VI (GPVI) is a platelet immune receptor tyrosine activated motif (ITAM) receptor for collagen , which plays an important role in vascular integrity in animal models of inflammation and sepsis
Glycoprotein VI (GPVI) is a platelet immune receptor tyrosine activated motif (ITAM) receptor for collagen , which plays an important role in vascular integrity in animal models of inflammation and sepsis .
In this flight study, 15 sepsis patients were continuously and comprehensively analyzed by flow cytometry, agglutination assay, and western blotting on the day they entered the intensive care unit (ICU), day 5 to day 7, and the day they were transferred out of the ICU
Decreased platelet activity in patients with sepsis
Decreased platelet activity in patients with sepsisThe analysis results showed that the platelet function of all patients was significantly reduced
The platelet function of all patients was significantly reduced .
Co-culture with whole blood of patients with sepsis can induce GPVI deficiency in platelets from healthy donors
Co-culture with whole blood of patients with sepsis can induce GPVI deficiency in platelets from healthy donorsThe platelets of patients with sepsis cannot transduce GPVI-mediated signals to trigger the tyrosine phosphorylation of Syk kinase or LAT
Co-culture of platelets from healthy donors with whole blood of patients with sepsis can induce partial GPVI defects in platelets of healthy donors, but co-culture with plasma from patients with sepsis has no such effect
In summary, since the weakening of GPVI signal occurs in the early stage of sepsis, this defect may be used as an indicator for the diagnosis of early sepsis , which needs to be further confirmed in prospective studies
Since GPVI signal reduction occurs early onset of sepsis, the defect or as diagnostic indicators of early sepsis early onset signal reduction occurs due GPVI sepsis, or as the defect diagnostic indicator of early sepsis diagnosis
Original source:
Original source:Weiss Lukas J,Manukjan Georgi,Pflug Annerose et al.
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