Blood: A unique process of hemoglobin removal in macrophages
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Last Update: 2020-07-13
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Source: Internet
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Author: User
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Hemoglobin is an important cofactor in a variety of cellular functions, but free hemoglobin released during hemolytic processes can lead to oxidative tissue damage,blood vesselsdysfunction and inflammationMacrophages play a key protective role in hemoglobin removal, but the mechanism for regulating the metabolic adaptation required to effectively degrade hemoglobin is unclearrecently published an article in Blood, Bories et aldemonstrate that hemoglobin loads drive a unique bioenergy shift in macrophages, from oxidation phosphorylation to glucose consumptionmetabolomics and transcription analysis of hemoglobin-containing macrophages showed that glucose entering the phosphate pathway (PPP) is necessary for the effective detoxification of hemoglobin and maintaining the balance of red blood oxideThe researchers also demonstrated that metabolic transfer to PPP is controlled by carbon monoxide (CO) production, which is dependent on hemoglobin oxygenasefinally, the researchers also found that in mouse SCDs, PPP was increased in organ systems associated with hemoglobin removal, and PPP activity was associated with hemoglobin levelsin general, the study showed that macrophage's metabolic adaptation to hemoglobin detoxification required a shift to carbon monoxide-induced PPCs derived from hemoglobin, suggesting that macrophage metabolism was a pharmacological target for a new treatment strategy, or an increase in hemoglobin removal rates in patients with hemolytic diseases
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