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The sensor was developed by a research team led by Dr.
Can Dincer and Dr.
H.
Ceren Ates, FIT Freiburg Interactive Materials and Bioinspiration Technology Center and Professor Wilfried Weber, Professor of Synthetic Biology and CIBSS Excellence Cluster-a lecture team of the Center for Integrated Biosignal Research Member, based on synthetic protein that reacts to antibiotics, resulting in electrical changes
.
The research results of the researchers are published in the "Advanced Materials" magazine
Previously, researchers could only detect traces of antibiotics in the breath
The researchers tested the biosensors on blood, plasma, urine, saliva and breath samples from pigs treated with antibiotics
.
They were able to prove that the results obtained with the biosensor in pig plasma were as accurate as standard medical laboratory procedures
Sensors can help critically ill patients keep antibiotic levels stable
Faced with threats such as sepsis, organ failure, and even death, doctors need to keep antibiotic levels within a personalized treatment range
.
Improper use of antibiotics may cause bacteria to mutate, causing the drug to no longer work: resistance to the drug
Bacterial protein as a sensor
The protein of this microfluidic biosensor can recognize lactam antibiotics, such as penicillin, and fix it on a polymer film
.
The antibiotic of interest in the sample competes with the enzyme-conjugated-lactam for binding to these bacterial proteins
Journal Reference :
H.