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    Home > Active Ingredient News > Antitumor Therapy > BJU Int: Clinicopathological predictors of inguinal lymph node metastasis in penile cancer patients

    BJU Int: Clinicopathological predictors of inguinal lymph node metastasis in penile cancer patients

    • Last Update: 2022-01-23
    • Source: Internet
    • Author: User
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    Penile cancer (PeCa) patients had a better 5-year cancer-specific survival rate (81%)
    .


    However, the 5-year cancer-specific survival rate for patients with lymph node metastases (LNM) averaged 56%


    Invasive nodule staging is required in the cN0 inguinal pelvis for early detection of these metastases to improve survival

    Recently, researchers from the Netherlands published an article in the journal BJU Int.
    They used dynamic sentinel node biopsy (DSNB) features to establish additional inguinal lymph node metastases after completion of inguinal lymph node dissection (ILND) in patients with positive DSNB.
    (LNM) prediction model with the aim of identifying patient populations that may be missed by ILND
    .

    Using dynamic sentinel node biopsy (DSNB) features, an additional inguinal lymph node metastasis (LNM) prediction model was developed after completion of inguinal lymph node dissection (ILND) in patients with positive DSNB, with the aim of identifying patient populations that may be missed by ILND utilizing dynamic sentinel Characterization of node biopsy (DSNB), after completion of inguinal lymph node dissection (ILND) in patients with positive DSNB, an additional inguinal lymph node metastasis (LNM) prediction model was developed with the aim of identifying patient populations that may be missed by ILND

    The study population was drawn from seven European centers and included 407 patients with DSNB-positive penile cancer who subsequently underwent ILND
    .


    The researchers conducted a retrospective study of their groin pelvis


    RESULTS: Among the positive DSNBs, 64 patients (16%) had additional LNM at ILND
    .


    Number of positive nodules with positive DSNB (odds [OR] 2.


    Calibration plot of the final model

    Calibration plot of the final model

    In conclusion, there is a small subset of clinically significant inguinal pelvises with additional LNM after completion of ILND in DSNB-positive patients
    .


    Although DSNB features were associated with additional LNM, they did not improve ILND selection for the inguinal pelvis


    There is a small subset of clinically significant inguinal pelvises with additional LNM present after completion of ILND in DSNB-positive patients


    Original source:

    Original source:

    Hielke M de Vries, Hack Jae Lee, Wayne Lam et al.


     

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