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General principles of cancer screening include the detection of clinically significant disease in an asymptomatic population with known natural progression, and early diagnosis and treatment that are effective in improving outcomes and reducing mortality
Recently, researchers from Finland published an article in BJU Int evaluating the feasibility of a population-based screening test using prostate-specific antigen (PSA), kallikrein panel and multiparametric magnetic resonance imaging (MRI).
Evaluated the feasibility of a population-based screening test using prostate-specific antigen (PSA), kallikrein panel, and multiparametric magnetic resonance imaging (MRI) and aimed to minimize overdiagnosis while preserving mortality benefits Evaluated the feasibility of a population-based screening test using prostate-specific antigen (PSA), kallikrein panel, and multiparametric magnetic resonance imaging (MRI) and aimed to minimize overdiagnosis while preserving mortality benefits
The researchers evaluated the feasibility of the screening algorithm in terms of engagement, screening test results, and cancer detection
Of the 399 men invited, 158 (40%) participated in the trial, of whom 27 had PSA levels ≥3 ng/mL (7% of invitees, 17% of participants)
Thus, additional testing (kallikrein panel and MRI) after PSA reduced biopsy rates by 56%
Outcomes of men with cancer screened in the study
Outcomes of men with cancer screened in the study
Taken together, their results demonstrate that their screening protocol is effective, substantially reducing the proportion of biopsies
Their results demonstrate that their screening protocol is effective, resulting in a substantial reduction in the proportion of biopsies
Original source:
Original source:Antti Rannikko, Mare Leht, Tuomas Mirtti et al.
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