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May 9, 2020 / / Research Background: Redsyvir (GS-5734) as a new, promising COVID-19 drug, its biological impact on the mammalian reproductive system has not yet been systematically studied.
In this way, researchers from the Department of Reproductive Medicine of Shenzhen Maternal and Child Health Hospital, the Institute of Translational Medicine of Shenzhen Second People's Hospital and the First Affiliated Hospital of Shenzhen University Medical Department conducted a study on the effects of Redsiway on sperm quality and sperm production in mice, and the results of the study were recently published on the preprinted platform bioRxiv, entitled "A preliminary study on the reproductiveity of GS-5734 on male mice".
image Source: bioRxiv Materials and Methods: Researchers have synthesized Redsiway based on the report.
then randomly divided 28 adult male mice into four groups (7 in each group).
group 1 was set up as a control group, and each mouse in groups 1, 2, 3 and 4 was injected daily through celiac injections of 0, 10, 50, and 150 μg of redsiwe for a total of 10 days.
7 days after the last injection, the researchers collected testicles and appendicular tails for HE staining and sperm concentration, vitality, and morphological analysis.
results: The researchers found that the total sperm population and active sperm rate of male mice showed a downward trend and abnormal sperm rate showed an upward trend after receiving Redsyve treatment.
Compared to the control group, treatment with a daily dose of 150 μg per mouse resulted in a significant decrease in sperm concentration and activity, while abnormal sperm rate increased significantly, and treatment at a daily dose of 50 μg per mouse significantly reduced sperm activity while increasing abnormal sperm rate.
HE staining of testicles and tissues attached to the testes showed a significant deterioration in sperm levels in mice, especially in the highest dose group, as the dose of Redsyves increased.
concluded that these results suggest that high doses of Redsyve treatment can cause testicular toxicity in mice, reducing sperm count and quality.
further study of Redsyve's reproductive toxicity is needed.
() Reference: Jing Fan et al. Preliminary study on the business toxicity of GS-5734 on male mice. bioRxiv. 2020. doi: https://doi.org/10.1101/2020.04.21.050104.
