Biorxiv: genetic changes or changes in the risk of Alzheimer's disease in individuals

February 8, 2020 / BIOON / -- recently, a research report published in the International Journal biorxiv, researchers from University College London and other institutions found that a gene involved PSEN1, the key gene of sexual and early-onset Alzheimer's disease, may be involved in the pathogenesis of various forms of the disease; PSEN1, which plays a key role in the basic cell process, will reduce or increase the risk of Alzheimer's disease Photo source: cc0 public domain researcher Katy Stubbs says diseases such as Alzheimer's are often inherited by age Factors, lifestyle and other mixed factors, and there are many factors that lead to the risk of individual disease; relevant research results show that the special changes of genes involved in maintaining the fine energy balance of cells may increase the risk of individual Alzheimer's disease, while other changes will help the body effectively resist the occurrence of disease Although genetic discovery is often an important starting point for the study of new therapies, it may be too early to conclude whether drugs that target the body's genetic pathway can help solve Alzheimer's disease without affecting other key cellular processes; PSEN1 causes rare genetics Sexual early-onset Alzheimer's disease, at the same time, the gene is also involved in the pathogenesis of this disease in many forms It is important for researchers to see more such studies use related gene clues to accelerate the major breakthrough of dementia research Finally, the researchers said that genetic factors play a key role in the risk of Alzheimer's disease We can't change the inherited genes Some studies believe that a healthy lifestyle can help us increase our odds; a healthy lifestyle of the brain includes keeping the body moving, eating a balanced diet, drinking within the recommended guidelines and not smoking Original sources: David Curtis, kaushiki bakaya, Leona Sharma, et al Weighted burden analysis of exit sequenced late onset Alzheimer's cases and controls provide further evidence for a role for PSEN1 and suggestions involvement of the PI3K / Akt / GSK-3 β and Wnt signaling pathways, biorxiv (2019) Doi: 10.1101/596007