Biorxiv: Chinese scientists reveal the potential T cell and B cell epitopes of 2019 ncov

February 26, 2020 / BIOON / -- as of February 26, 2020, 2019-ncov has infected more than 77000 people in more than 26 countries, taking more than 2000 lives 2019-nCoV is a novel coronavirus that causes COVID-19, which is highly similar to SARS-CoV No vaccine has been approved for 2019 ncov or any form of coronavirus Photo source: Recently, Chen Binbin and Ethan fast from Stanford University School of Medicine published an up-to-date article entitled "potential T-cell and B-cell Epitops of 2019 ncov" on the preprint website biorxiv In this paper, researchers used computational tools from structural biology and machine learning to identify T and B cell epitopes of 2019-ncov based on the binding characteristics of viral protein antigens and antibodies These epitopes can be used to develop more effective vaccines and to identify neutralizing antibodies The researchers identified 405 viral peptides with good antigen expression scores in human MHC-I and MHC-II alleles, and found two potential neutralizing B cell epitopes (440-460 and 494-506) near the receptor binding domain of 2019-ncov s protein By analyzing the mutation spectrum of 68 virus genomes from four continents, the researchers found 96 coding mutations These mutations were more likely to occur in areas with better MHC-I scores (P = 0.02) There was no mutation near the binding region of S protein receptor Finally, the researchers used the SARS CoV experimental data to verify our calculation method Reference: Binbin Chen et al Potential T-cell and B-cell Epitops of 2019-ncov Biorxiv Doi: https://doi.org/10.1101/2020.02.19.955484