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April 18, 2020 / / - With the widespread spread of SARS-CoV-2 and the global pandemic of COVID-19 and the proliferation of cases worldwide, there is an urgent need to improve the treatment of COVID-19 disease and develop new drugs.
at Hamad bin Khalifa University, Warwick University and the University of Qatar say chemotherapy may be a strategy to deal with SARS-CoV-2.
This is because chemotherapy drugs can increase levels of endogenetic reaction metabolites, such as reactive oxygen and arginine-directed glycodides, methyl acetaldehyde (acetone), and so on, so it is expected to produce selective toxicity to SARS-CoV-2, the relevant research results Recently published on the preprinted platform bioRxiv, entitled "The Files of the SARS-CoV-2 virus to proteotoxicity - opportunity for repurposed processy of COVID-19 infect".
photo source; bioRxiv researchers analyzed sequences of SARS-CoV-2 proteogroup functional domains and found that cysteine residues were reduced by 0.8 times and arginine residues increased 4.9 times, suggesting that methyl acetaldehyde modification may have inactiveated the virus.
researchers also found MG-modified peptide sequences: cation residues increased three to five times before the target.
, the number of methyl acetaldehyde modification points in the SARS-CoV-2 protein group increased fivefold compared to human hosts, indicating the selective toxicity of methyl acetaldehyde to the virus.
using cellular experiments, researchers have found that anti-tumor drugs -- amycin and yew alcohol -- can increase methyl acetaldehyde in cells to levels that kill the virus.
above, these findings reveal that SARS-CoV-2 proteomics is susceptible to methyl acetaldehyde modification and provide a theoretical basis for the reuse of amycin and yew alcohol for COVID-19 therapy.
() Reference: Maryam Al-Motawa et al. Blyps of SARS-CoV-2 virus to proteotoxicity - opportunity for repurposed icingy of COVID-19. bioRxiv. 2020. doi: https://doi.org/10.1101/2020.04.07.029488.
