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Biological Psychiatr: Imbalanced temporal proportion of different brain states is a marker of cSVD-related cognitive decline

 Last Update: 2022-05-23
 Source: Internet
 Author: User

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Clinical manifestations of cerebral small vessel disease (cSVD) include stroke, depression, and cognitive impairment

Dynamic functional connectivity (dFC) studies have revealed spatiotemporal organization that cannot be assessed with static functional connectivity methods, including brain states with multiple, temporally isolated, synchronized brain activity patterns

Eckhard Schlemm MBBS et al.

This study quantified cSVD by white matter hyperintensity (WMH) and skeletonized mean diffusivity peak width (PSMD)

The study analyzed data from 979 participants (aged 45-74 years, median WMH volume 0.

Relationship between white matter lesion volume and occupancy fraction (FO)/mean dwell time (DT)

Clustering identified five brain states with the most time spent in the activated (+) or inhibited (-) states of the default mode network (occupancy ratios: DMN+ 25.

The study found that increased WMH burden was associated with decreased time in high-occupancy brain states and increased time in low- occupancy brain states

This study presents for the first time the characterization of brain-wide spatiotemporal co-activation patterns present in cSVD and their correlation with associated cognitive deficits

original source
Equalization of brain state occupancy accompanies cognitive impairment in cerebral small vessel disease, Biological Psychiatry, 2022, ISSN 0006-3223, https://doi.

Equalization of brain state occupancy accompanies cognitive impairment in cerebral small vessel disease, Biological Psychiatry, 2022, ISSN 0006-3223, https://doi.
org/10.
1016/j.
biopsych.
2022.
03.
019.

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