Biological activity of chlorogenic acid

Last revision: 2013-03-12 02:32 classification: efficacy 0 people commented that chlorogenic acid is composed of caffeic acid and quinic acid It is also known as 3-caffeoylquinic acid Its chemical name is 3-o-caffeoylquinic acid It is a phenylpropanoid compound produced by plants through the mangrove acid pathway during aerobic respiration Hyaluronidase (HAase) is one of the enzymes that cleave mucopolysaccharide It can catalyze the breakdown of hyaluronidase (HA), which is related to the permeability and inflammation of vascular system Ha is a kind of mucopolysaccharide composed of glucuronic acid and acetylglucosamine It has many functions, such as healing wounds, moistening skin, lubricating joints and preventing inflammation Therefore, a variety of active ingredients which can inhibit the activation of naase were found in the natural products, but also have strong anti allergic activity It is expected to be used as a leading compound for further development of new anti allergic drugs It was found that 3,5-dicaffeoylquinic acid (DCQA) and chlorogenic acid (IC50 of 1-85 and 2-25mmol / L, respectively) had a strong inhibitory effect on the activation of naase Glucose-6-phosphatase system (g1-6-pase) plays an important role in the regulation of blood glucose homeostasis It is responsible for the formation of endogenous glucose from gluconeogenesis and glycogenolysis Recently, chlorogenic acid has been identified as the first novel specific inhibitor of glucose-6-phosphotransferase (g1-6-p-trnaslocase) in rat liver microsomes By measuring the degree of g1-6-p hydrolysis in normal rat liver microsomes, the inhibitory intensity of chlorogenic acid and its synthetic analogues on the activity of displacement enzyme was determined Studies at home and abroad have shown that chlorogenic acid is an effective phenolic antioxidant, and its antioxidant capacity is better than caffeic acid, p-hydroxybenzoic acid, ferulic acid and Syringate, as well as common antioxidants, such as butylhydroxyanisole (BHA) and tocopherol, but it is equivalent to butylhydrotoluene (BHT) 1-3 scavenging free radical chlorogenic acid and its derivatives have stronger scavenging effect than ascorbic acid, caffeic acid and tocopherol It can effectively scavenge DPPH free radical (1,1-diphenyl-2-picrylhydrazy1), hydroxyl free radical and superoxide anion free radical It can also inhibit the oxidation of LDL Chlorogenic acid can effectively eliminate free radicals in the body, maintain the normal structure and function of cells, prevent and delay the occurrence of tumor, mutation and aging Chlorogenic acid has a strong ability to inhibit mutation, it can inhibit the mutation caused by aflatoxin Bi and the mutation caused by sub digestive reaction, and can effectively reduce the mutation of bone marrow erythrocytes caused by y-ray; at the same time, chlorogenic acid can also achieve the effect of cancer prevention and anti-cancer by reducing the utilization rate of carcinogens and their transport in the liver It can also inhibit cancer caused by benzopyrene and 4-nqo (nitroquinoline oxide) Chlorogenic acid has a significant inhibitory effect on colorectal cancer, liver cancer and laryngeal cancer It is considered to be an effective chemical preservative J for cancer Lou Hongxiang, et al Obtained chlorogenic acid tetraacetylation from the water-soluble part of honeysuckle after acetylation The pharmacological experiment showed that it had obvious protective effect on the liver injury of mice caused by carbon tetrachloride, which provided a theoretical basis for clarifying the effect of honeysuckle on protecting liver and promoting gall Lijisu also has the effect of cholagogue and liver protection Isochlorogenic acid B can promote the release of prostacyclin (PGI2) and inhibit platelet aggregation in rats, and the inhibition rate of SRS-A release induced by antibody induced by pulmonary debris in guinea pigs is 62-3 In addition, it has a strong inhibitory effect on thromboxane biosynthesis and hydroperoxides induced endothelial cell injury It has been reported that chlorogenic acid and isochlorogenic acid have strong inhibition and killing effects on a variety of pathogens and viruses It has obvious curative effect on acute pharyngeal inflammation and dermatosis, and is used in the treatment of acute bacterial infection Caffeic acid, the hydrolysate of chlorogenic acid, also has the functions of whitening, hemostasis, cholestasis and herpes simplex virus inhibition Recently, it was reported that Professor EICH of Free University in Germany, when studying some plant secondary metabolites as antiretroviral agents, thought that chlorogenic acid is a promising lead compound against Aizai virus (H1V) This is consistent with the conclusion that the basic extract of eucommia bark or leaves is effective in the treatment and prevention of HIV infection.