Biochem Pharmacol: a new method for promoting the maturation of cardiac cells

October 15, 2019 / BIOON / -- scientists from Masonic Medical Research Institute (mmri), in cooperation with nanion technologies, recently published a study on biological pharmacology, which solved the problem of potassium current deficiency in human induced pluripotent stem cell-derived cardiomyocytes (HIBS c-cms) "Haips CS have changed medical research; it's a tool that can provide therapeutic strategies by accurately analyzing the genetic makeup of patients' diseases," said Dr Jon Cordeiro, a research scientist at mmri Photo source: biological pharmacology this article can now be found on the biomedical pharmacology website Hipscs are stem cells extracted from human skin or blood, which can be transformed into different types of cells, such as cardiomyocytes - muscle cells of the heart These h IPS c-cms can be used in a variety of applications, including safety pharmacology "However, although h IPS c-cms has potential applications in many aspects of research, it has not fully developed into mature adult heart cells, and they have defects in several important K + currents," said Jacqueline treat, first author "The lack of K + current indicates a low repolarization reserve in cells, which limits their ability to beat normally and may lead to arrhythmias or irregular heartbeat," added Robert goodrow, coauthor In this study, mmri scientists determined whether the stimulation of H IPS c-cms by two different types of K + channel activators, i.e instantaneous outward K + current (ITO) and fast delayed rectifier K + current (IKr), could improve the repolarization reserve and produce more mature cardiac cells These experiments focus on the field of electrophysiology, that is, studying the electrical properties of biological cells and tissues The results show that in hiPSC CMS, the activator can only enhance the IKr current, but not the ITO current However, IKr alone improved the repolarization reserve of hiPSC CMS and differentiated cardiac cells more fully In addition, their study also accidentally found that only one K+ channel in H IPS C-CMs is induced by two activators; in mature heart cells, the same activator can activate two channels at the same time These data suggest that the conclusion of the pharmacological action between the c-cms and mature adult heart cells needs to be reviewed Reference materials: Jacqueline treat et al Pharmaceutical enhancement of replication reserve in human induced pluripotent stem cells derived cardiometrics Biological pharmacy volume 169, November 2019113608 Doi: https://doi.org/10.1016/j.bcp.2019.08.010