Bio Valley Recommendation: Top10, a must-see heavy-weight study from November to December

Previous studies have shown that ingesting red peppers has anti-inflammatory, antioxidant, anti-cancer and blood sugar-regulating effects, perhaps thanks to capsaicin, which helps people eat chili peppers. To analyze the effects of red pepper intake on all-cause mortality and cardiovascular mortality in the population, the researchers screened 4,729 studies from five major global health databases, including four large studies that included data on participants' health and red pepper intake.
5: Cancer Cell overview article interpretation! How to develop a new generation of cancer therapy for CAR-T cell engineering modification? Doi:10.1016/j.ccell.2020.07.005 A review published in the international journal Lancer Cell entitled "Car Engineering CAR-T Cells for Next-Generation Cancer Therapy" by scientists from the University of California and others discussed how CAR-T cells can be engineered for use as a new generation of cancer therapy.
Engineered T-cells that express tumor-specific chilayer antigens (CARs) have achieved remarkable results in treating patients with malignant blood tumors, while also revolutionizing the field of step cell therapy, but multi-layered engineering is needed to achieve wider therapeutic applications of CAR-T cells Improving the efficacy and safety of treatment, especially since the biological complexity of the tumor microenvironment (TME) often presents unique challenges to its treatment, the researchers discuss the latest strategies for improving CAR-T cell therapy by engineering the interactions between CAR proteins, T cells, T cells, and other components in TME.
photo Source: CC0 Public Domain 6 Nat Cancer: Combining CAR-T cell therapy with special inhibitor drugs or promising to treat multiple types of cancer! doi:10.1038/s43018-020-00147-8 Intricate vascular "maze" in the micro-environment of tumors remains one of the most difficult obstacles to cell therapy penetration and treatment of solid tumors. In a study published in the international journal Nature Cancer, scientists from the University of Pennsylvania's Perelman School of Medicine and others found that combining CAR-T cell therapy with PAK4 inhibitors could significantly improve survival in mice by promoting engineering cells to break through and attack tumors.
researchers found in the lab that hemangiogeneization of solid tumors is driven by the genetic reprogramming of tumor endothotres caused by PAK enzymes, which in mouse models of glioblastoma knock out the enzyme or reduce the abnormal distribution of blood vessels in tumors, and improve the leaching of T-cells and immunotherapy of CAR-T cells, the most common malignant brain tumor in the United States, with more than 22,000 cases each year.
: Sci Transl Med: New Discoveries! The body's stress hormones may promote the recovery of dormant cancer cells causing the cancer to return! Doi:10.1126/scitranslmed.abb5817 In a recent study published in the international journal Science Translational Medicine, scientists from the United States, Germany and other countries have jointly found that natural stress hormones may reactivate dormant cancer cells in mouse bodies, and that the results may help develop new treatments for cancer.
Now that medical scientists have been trying for years to understand why cancerous tumors sometimes relapse years after initial successful treatment, researchers have found evidence that cancer recurrence occurs when dormant cancer cells are awakened by stress hormones in the patient's body.
Previous studies have shown that when cancerous tumors begin to grow, some cells move to other nearby locations and go into a dormant state, which seems unlikely to be killed or removed by surgery or chemotherapy because they are far away and dormant.
(8) Cell Rep: Scientists have developed a new method or energy source to produce hematopoietic stem cells doi:10.1016/j.celrep.2020.108474 In a recent study published in the international journal Cell Reports, scientists from institutions such as the Spanish Genome Control Center and Columbia University identified a specific protein that is critical to the expansion of scarce, life-saving blood stem cells.
Research may help scientists develop new ways to reproduce large numbers of these stem cells in and out of the body, which are currently one of the biggest limitations scientists use in a variety of medical procedures, from treatments for blood cancer to genetic blood diseases that require bone marrow transplants.
Hematopoietic Stem Cells (HSCs), which are responsible for the continuous renewal of blood, produce billions of new cells every day, and HSCs have unlimited potential to self-renew throughout the life cycle of an organism and produce every type of blood cell, including the cells that make up our body's immune system.
HSCs also have great potential to treat a variety of incurable cancers, autoimmune diseases and hereditary blood disorders, yet only one in 2,500 cells in the bone marrow is hematopoietic stem cells, a scarcity that may greatly limit the use of hematopoietic stem cells in medical procedures.
: Nat Commun: Intestinal bacteria play a key role in brain function and the body's emotional regulation! doi:10.1038/s41467-020-19931-2<!--/ewebeditor:page-><!--ewebeditor:page-">"In a recent study published in the international journal Nature Communications, scientists from institutions such as the Pasteur Institute found that imbalances in the gut bacteria may contribute to lower levels of certain metabolites, leading to depression-like behavior in the body, suggesting that healthy gut bacteria may promote normal brain function.
group of bacteria in the gut, commonly known as the "intestinal bacterium", is the largest reservoir of bacteria in the body, and now more and more research shows that the host and gut bacterium are good examples of a mutually beneficial interaction, and recent observational findings have revealed the body's mood disorders and intestinal bacteria. The link between injury comes after researchers found a link between gut bacteria and the molecular physiency of fluoxetine, a molecule commonly used as a depression drug, but researchers do not yet know the molecular mechanisms that control the development of depression, which is now a major cause of disability in the global population.
10 Cell heavy interpretation! Obesity impairs the function of immune cells and accelerates the molecular mechanisms of tumor growth! doi:10.1016/j.cell.2020.11.009 Obesity is associated with an increased risk of more than a dozen different types of cancer, as well