Bio Valley recommendation: September must-see heavyweight study Top10.

!-- webeditor: page title" -- In a blink of an eye September is drawing to a close, what are the highlights of this month worthy of our in-depth study? Based on the type, heat, and field of study of this month's news, the editor-in-chief selected this month's heavyweight study Top10 to learn from.
Photo Source: SIAT1 Nat Med: Dual-CAR-T Cells, Developed targeting HIV library, lay the groundwork for a cure for HIV infection Doi:10.1038/s41591-020-1039-5 In a new study, researchers from the Lagan Institute, the University of Pennsylvania and Massachusetts General Hospital describe a new type of dual CAR-T (CAR T cell), Dual-CAR-T) cellular immunotherapy can help fight HIV infection, the study was published in the journal Nature Medicine.
, "This study highlights how relatively direct changes in the way T cells are modified can lead to dramatic changes in their potency and persistence."
findings are important for using T-cells to fight HIV and cancer.
" global HIV epidemic affects more than 35 million people worldwide.
antiretroviral therapy (ART) is a routine treatment that controls but does not cure HIV infection.
, however, access to and lifetime adherence to daily treatment is a major challenge for many people living with HIV.
major obstacle to HIV cure is the virus library, a copy of HIV hidden in the genome of infected cells.
IFART treatment is stopped, the virus can quickly produce new copies of HIV, which eventually leads to AIDS.
: Cell Res: Breakthrough! Chinese scientists have discovered for the first time that SARS-CoV-2 could potentially infect human nerve cells and brain-like organs! Doi:10.1038/s41422-020-0390-x In a recent study published in the international journal Cell Research, scientists from the Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences and the University of Hong Kong found that SARS-CoV-2 may infect human nerve cells and brain-like organs.
SARS-CoV-2 induces COVID-19, a new type of coronavirus infection, and as of August 3, 2020, there were more than 17 million COVID-19 patients worldwide, of whom more than 686,703 died.
The new coronavirus mainly causes respiratory diseases and clinical symptoms are very similar to SARS infections, however, patients with COVID-19 often report a variety of neurological symptoms such as headaches, insomnia, Alzheimer's disease, confusion, epilepsy and brain disease.
study of 214 PATIENT COVID-19 patients admitted to hospital in Wuhan showed that 36.4% of patients and 45.5% of severe cases had neurotic symptoms, and studies conducted in France and Germany also found that 84.5% and 36.4% of COVID-19 patients had brain infections.
, however, there is no experimental evidence that SARS-CoV-2 can cause infections in the human central nervous system.
: Ebio Media: New Discovery! Eating a ketogenic diet may help reduce the risk of Alzheimer's disease induced by intestinal fungi! doi:10.1016/j.ebiom.2020.102950 Recently, an article published in the international magazine Ebio Mediaine entitled "Gut mycobiome and its interaction with diet, In a study by Gut bacteria and alzheimer's disease markers in subjects with mildial impairment: A pilot study, scientists from institutions such as Wake Forest University Baptist Medical Center found that specific fungi in the gut were directly related to an increased risk of Alzheimer's disease in individuals, and that improved Mediterranean diets could improve the risk of Alzheimer's disease in individuals with mild cognitive impairment in a beneficial way.
researcher Professor Hariom Yadav said the study revealed special fungi that symbly co-live with gut bacteria in individuals with mild cognitive impairment (MCI) by eating a Mediterranean ketogenic diet.
In this paper, researchers conducted a single-center, randomized double-blind cross-study of participants with a modified six-week Mediterranean ketogenic diet intervention or the implementation of the American Heart Association's dietary strategy. The RNARNA1 gene sequenced to identify specific groups in the gut microbiome, including 11 individuals diagnosed with mild cognitive impairment and 6 individuals with health conditions, and the researchers aimed to determine the association between alzheimer's biomarkers and gut microbiomes in the body's cerebrospinal fluid.
: JAMA Network Open: Body deficiency of vitamin D may increase an individual's risk of COVID-19 doi:10.1001/jamanetworkopen.2020.1972 In a recent study published in the international journal JAMA Network Open, scientists from the University of Chicago Medical Center and other institutions revealed a link between vitamin D deficiency in the body and the risk of individual infection with SARS-CoV-2 in retrospective studies of patients with COVID-19. david Meltzer,
M.D., said vitamin D is critical to the body's immune system's functioning, after previous studies have shown that vitamin D supplements may be effective in reducing the risk of respiratory viral infections, and statistical analysis in this paper suggests that vitamin D supplementation may be promising to treat SARS-CoV-2 infections. In the
article, researchers studied 489 patients who had been tested for the body's vitamin D levels in the year prior to their diagnosis of COVID-19, and found that untreated vitamin D deficiency patients were almost twice as likely to develop COVID-19 as individuals with adequate vitamin D levels.
!--/ewebeditor:page--!--ewebeditor:page title"--Cell: More than 7,000 genetic regions in the human genome that control blood cell properties are expected to predict the risk of rare and common blood diseases in the population doi:10.1016/j.cell.2020.08 Now two large-scale genetic studies have identified most of the genetic mutations that affect the important medical characteristics of the body's blood cells, and in a recent study published in the international journal Cell, scientists from 101 research institutions around the world, including the Sanger Institute at the University of Cambridge, studied thousands of participants around the world and identified more than 7,000 regions in the human genome that can control the properties of blood cells, including red blood cells and the number of white blood cells.
paper, researchers explain for the first time how a person's genetic make-up induces his or her blood disorders, and the findings may help researchers use genetic scoring tools in clinical trials to predict an individual's risk of developing blood disorders.
blood cells play a critical role in human health, including the body's immune response, the transport of oxygen, the formation of clotting to prevent blood loss from wounds, and blood disorders such as anemia, haemophilia and blood cancer may be an important burden on global health.
Many of these diseases are considered extremes of normal biological conditions, such as anemia, in which the patient's body tends to suffer from hypoxia due to too few red blood cells, which may also be caused by small mutations in the body's DNA, some of which also increase the risk of disease in the individual.
picture source: PNAS, 2020, doi:10.1073/pnas.2008615117 PNAS: Function doi:10.1073/pnas.20066031117, a function that divides immunotoxins into two functions or promises to kill cancer cells with precision without damaging healthy cells. In a study published in the international journal PNAS, scientists from Ohio State University and other institutions found that spliting an anticancer drug in two and then giving cancer cells, or effectively reducing their life-threatening side effects, also protects healthy non-cancerous cells from being affected;
Immune toxins combine immune substances with toxins, which can absorb cancer cells, promoting toxins into cancer cells and killing them without damaging nearby healthy cells; the study was designed as a proof-of-concept study, but the researchers found that they were able to reconstruct the functional toxin in cell cultures in the lab and cancer cells in mice.
Scientists' research into cancer therapies has now helped develop a number of effective treatments that not only destroy cancer cells, but also healthy non-cancerous cells, and that can have life-threatening side effects; the problem, says researcher Dmitri Kudryashov, is that we don't want to kill healthy cells, and the challenge now is how to kill only cancer cells without affecting their function.
: Liver Transpl: Heavy! Scientists have successfully bred functional liver tissue in pigs' lymph nodes! Doi:10.1002/lt.25872 The liver's main functional cell, the liver cell, is a natural regenerative cell, and the lymph nodes are a "hotbed" for reproduction, according to a recent study published in the international journal Liver Transplantation, in which scientists from institutions such as the University of Pittsburgh found that large animals with livers could use their own liver cells to grow a new liver in the lymph nodes, and the next researchers plan to conduct human clinical trials.
researcher Dr Eric Lagasse says all this may be related to important locations, where liver cells form hetero-liver tissue at lymph nodes if they reach the exact location and need liver function; cells in the liver usually replenish themselves, but need a healthy, nutritious environment to regenerate, but in the advanced stages of liver disease, the patient's liver is bound by scar tissue and cannot recover from cell toxicity.
the body's liver is constantly regenerated, and liver cells try to repair their original liver tissue, but for a variety of reasons it often doesn't work and eventually dies.
About 10 years ago, researcher Lagasse noted that if healthy liver cells were injected into the lymph nodes of mice, they would multiply in large numbers and form an auxiliary liver tissue to take over the task of the original liver, which is genetically causing dysfunction, but the mice were smaller, and researchers needed to use large animal studies to analyze whether a meaningful secondary liver tissue could be grown to overcome liver disease.
. JAMA Netw Open: Regardless of overall alcohol consumption, drinking tablets significantly increases an individual's risk of developing dementia Doi:10.1001/jamanetworkopen.2020.16084 Individuals with alcohol use disorders tend to have a higher risk of dementia, and alcohol abuse is a target for successful dementia prevention Alcohol induces brain atrophy and is accompanied by the loss of neurons, especially in the preleual cortical layer of the brain; inflammation of the central nervous system, hypoglycemia, epilepsy and depression are all risk factors for dementia, and the effects of alcohol on dementia may be indirect, reflected in a variety of diseases associated with dementia, such as liver and kidney disease, diabetes, high blood pressure, arrhythmics and coronary heart disease.
There is current research evidence that alcohol consumption as a risk factor for dementia is often associated with individual alcohol consumption as a whole, but researchers do not know the key role that alcohol-induced brain loss plays in the development of dementia, " said a paper published in the international journal JAMA Network Open. In the for Dementia study, scientists from institutions such as University College London revealed a link between alcohol-induced loss of consciousness and overall alcohol consumption and individual dementia, and whether 14 potential alcohol-related diseases mediated an association between alcohol-induced loss of consciousness and dementia events, including diabetes, high blood pressure, Cardiovascular disease, liver and kidney disease, etc.
/!--/ewebeditor: page -- !--webeditor: page: title" -- 9 Cancer Res: Incredible! Increased growth hormone levels may increase the body's risk of multiple cancers! Doi:10.1158/0008-5472.CAN-20-1281 In a study published in the international journal Lancer Research, scientists from Oxford University and others studied nearly 400,000 people in the UK and found a link between elevated levels of the growth factor IGF-1 and an increased risk of thyroid cancer in the population.