Bilirubin is a stroke protection factor! Latest Analysis of CSPPT

Recently, an after-the-fact analysis of a Chinese stroke primary prevention trial (CSPPT) showed that in patients with hypertension, serum total bilirubin or direct bilirubin was associated with the risk of first ischemic stroke strokeStudies have shown that in patients with hypertension, the risk of stroke in the first ischemic stroke was reduced by 25% compared to those with the first serite serum bilirubin level (9.3 smol/L)The study also found that those with direct bilirubin trinograms (2.5 to 24.8 smol/L) also had a 23 percent lower risk of stroke for the first ischemic stroke than those with the first-level level (1.6 smol/L)Figure 1 Seroser total bilirubin or direct bilirubin was negatively associated with the risk of first ischemic stroke in hypertensive patients, however, no serotonin and direct bilirubin levels were found to be associated with first hemorrhagic strokeSerum bilirubin, an endogenous antioxidant, is positively correlated with the body's total antioxidant capacity, after previous studies have shown that its antioxidant activity is not related to its formIt has also been found that serum bilirubin is associated with oxidation of lipids and lipoproteins and endothelial damage, which in turn contributes to the formation of arterial porridge plaques and arterial thrombosisPrevious studies have also shown that people with type 2 diabetes have improved antioxidant and endothelial-dependent vascular diastolic abilities after applying the increased bilirubin drug AzanavirIf the study is further confirmed in the future, the researchers said, routine testing of bilirubin may help identify ischemic stroke in patients with high blood pressureThe study included 19906 patients with hypertension in the CSPPT trial, and 608 people had stroke during a median follow-up period of 4.5 years, including 489 ischemic strokes, 117 cases of hemorrhagic stroke, and 2 cases of ambiguous type strokeSource: Wang J, Zhang X, Zhang Z, et alBaseline Baseline Bilirubin and Risk of First in Strokeve Patients (public lyn online of the print, 2020 Jun 3)J Am Heart Assoc2020; e015799Author: Xi Xi Source: China Circulation Magazine