Big discovery! The psychiatric drug lipeone may be a boon for stuttering patients

The number of famous people who have suffered from stuttering disease in ancient and modern China and abroad is innuendo, Biden, Churchill, King George VI of England, Lu Xun, Guo Moruo, Ba Jin, Sima Xiangru, Li Guang... While their story of overcoming stuttering with a strong personal will is admirable, the difficulty is also frightening.
Thankfully, thanks to advances in neuroscience and brain science over the past few decades, the cause of stuttering has become clear, and the medical community has found that the human body's important tissue, the "brain", is the main cause.
recently, Gerald A. A., professor and chairman of the Department of Psychiatry and Neuroscience at the UCR School of Medicine. In an article published in Frontiers in Neuroscience entitled Investigation of Risperidone Treatment Associated With Enhanced Brain Activity in Patients Who Stutter, Dr. Maguire integrated functional neuroimaging techniques into stuttering therapy and found that the drug libido, previously earmarked for schizophrenia and bipolar disorder, may have some effect on stuttering, and that its function may be related to astrocytes in the brain streatum.
2019, PNAS published a study entitled Human GNPTAB Stuttering mutations into mice cause vocalizations and astrocyte pathology in the corpus callosum that speculated that in mouse stuttering models, the number of astrological glial cells in a subpoptonic group in the carbide decreased, indicating that stuttering was associated with neurogliopathy.
dopamine levels were associated with decreased activity of star-shaped glial cells in the synth.
earlier studies have found that libido, a psychotic drug, can act as a second-generation dopamine antagonist, blocking dopamine-acting subjects in the brain and thus preventing excessive dopamine activity.
these conditions suggest that dopamine antagonists may be a potential drug to treat stuttering in the context of a lack of stuttering drugs.
new study, researchers used neuroimaging techniques to visualize brain changes in stutterers to help optimize the results.
conducted a randomized, double-blind, placebo-controlled clinical trial of 10 adult subjects to observe the effects of lipester on brain metabolism.
subjects were given a separate reading task six weeks after taking lipesterone (0.5-2.0 mg/day) or a placebo.
the same time, fluorodesic glucose-positive electron layer scans (FDG-PET) were performed on everyone. the
study found that the frequency and duration of stuttering in the lipeone treatment group were reduced, and that the subjects showed higher glucose intake, or higher metabolism, in specific areas of the brain, which strongly confirmed the hypothesis that asailant glial cells may play a major role in stuttering development.
However, because the sample size of the study was too small and the imaging techniques involved in radiation exposure were relatively limited, the researchers did not find the exact mechanism by which libido activates astrological glial cells in the symposome, but speculated that lipeone may have affected neurons in the symposome by activating astrological glial cells to release a signal molecule that blocks its dopamine subjects.
Future researchers hope to use neuroimaging techniques to visualize brain changes in stutterers to find this signaling molecule and better understand the exact role of asstary glial cells to design effective drugs for the treatment of stuttering by astrological glial cells.
, the UCR School of Medicine has signed a research partnership with the U.S. National Institute of Neurology and Stroke to conduct research on stuttering.
hope that future researchers will work to better understand the causes of stuttering and the different types of stuttering, providing targeted personalized treatments for stutterers.
references: s1#B34 s.2#B41