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For medical professionals only
Bicken Propano tablets: the best choice of the "troika" era
"The original price of more than 1,000 drugs now only needs to pay 234~416 yuan, benefiting many HIV-infected people
.
" Zhao Wenxuan, chief physician of the Department of Infectious Diseases at Xianyang Central Hospital, said
.
The drug he was referring to was Bicken Pronor,
the original anti-HIV drug.
On December 3, 2021, the National Basic Medical Insurance, Work-related Injury Insurance and Maternity Insurance Drug Catalogue (2021) (hereinafter referred to as the "Catalogue") was officially released
.
The Catalogue includes many original drugs with good clinical efficacy and high patient recognition into the reimbursement list
.
The original anti-HIV new drug Bicken Prenols tablets are also among them, which are included in the scope of medical insurance reimbursement and the "dual-channel" management list, and can enjoy medical insurance reimbursement prices
when purchased in designated hospitals and designated retail pharmacies.
"Making policies work for those who really need them"
Director Zhao Wenxuan introduced that after the publication of the "Catalogue", Shaanxi Province quickly established a supporting payment policy, and included "dual-channel" drugs with a long use cycle and outstanding efficacy such as Biken Pronols tablets into the province's reimbursement catalogue to protect the rights and interests of
patients.
"Shaanxi has established an interconnection mechanism for medical insurance agencies, designated medical institutions, and designated retail pharmacies, introduced intelligent monitoring, cracked down on the use of 'dual channels' to obtain medical insurance funds, supervised the whole process of medication use by HIV-infected people, and ensured that medical insurance policies benefited those who
really needed them.
" ”
At the same time, Shaanxi adheres to the principle of "let information run more, patients run less", optimize the patient reimbursement service process, and realize the "dual-channel" one-stop settlement
of drugs.
At present, the "dual-channel" direct settlement of drugs purchased from different places is being promoted, and in the future, people with HIV infection in Shaanxi can directly enjoy medical insurance reimbursement prices when purchasing drugs at any designated institution in the province
.
"The entry of Bicken Prenol's tablets into medical insurance can also effectively combat black market generic drugs, improve access to treatment, and allow more infected people to obtain regular drugs
.
" Director Zhao Wenxuan said that in the past, the price of original drugs was high, medical insurance was not reimbursed, and many HIV-infected people who could not tolerate the side effects of free national drugs would choose to buy illegal generic drugs
from foreign purchasing and other channels.
Some infected people are ineffective and their conditions worsen after taking them, and some infected people are resistant to drugs, and their lives and health are seriously threatened
.
"In the past, I often encountered infected people holding generic drug bottles to ask if I could eat it, but now with the landing of medical insurance policies, few people ask this anymore
.
" "The price of illegal generic drugs has no advantage
compared with the current price of Bicken Pronorium tablets after medical insurance reimbursement.
"An infected person told me that the generic drug he used to buy was much
more expensive than the current price after reimbursement of BinFenbolol tablets.
”
Bicken Propano tablets: the best choice of the "troika" era
"Now HIV treatment is the era of the 'troika', which is divided into free drugs by the state, partially reimbursed drugs by medical insurance and fully self-paid drugs
.
" Director Zhao Wenxuan said that as a triple single-tablet compound preparation, Bicken Pronols tablets only need to eat one tablet a day to achieve the therapeutic effect of traditional drug multi-tablet combination, without the need to take other HIV-related drugs
.
Bickenpronol tablets are composed of
the powerful backbone drugs emtricitabine (F) and tenofovir propofovir (TAF), a dinucleoside reverse transcriptase inhibitor (NRTI), and the innovative integrase inhibitor bic tepiravir (BIC).
Its backbone drugs F and TAF can block reverse transcriptase, and BIC can inhibit viral integrase and block viral integration into host DNA
.
Director Zhao Wenxuan pointed out that Bicken Pronol tablets can achieve rapid virological suppression, long-term high efficiency, 5-year HIV suppression rate as high as 99
%.
[1] "Low drug interaction is a major advantage
of Bicern Pronol.
With the advancement of medical standards, most people with HIV can survive for a long time, which has led to an increasing number of
elderly people with HIV.
Many elderly people have underlying diseases such as cardiovascular and cerebrovascular and endocrinology, and need to take relevant drugs
for a long time.
"The advantages of Bicken Pronols tablets make them basically unnecessary to monitor and adjust the dose when combining drugs, which reduces the burden of medical treatment for infected people and improves treatment compliance
.
" "
Many infected people are worried about drug resistance caused by long-term drug use
.
" The barrier to resistance to Birkenprenol tablets is high, and no resistance associated with Bickenprenol tablets was
detected at 5-year follow-up in treatment-naïve adults.
”
With its therapeutic effect, Bicken Pronols tablets have been recommended
by many authoritative guides at home and abroad.
2020 International Antiviral Society-USA (IAS-USA) "Antiretroviral Drugs for the Treatment and Prevention of HIV Infection in Adults – 2020 International Antiviral Society-US Expert Group Recommendations", 2021 US Department of Health and Human Services (DHHS) "Guidelines for the Use of Antiretroviral Drugs in HIV-Infected Adults and Adolescents", 2021 European Society for Clinical AIDS (EACS) AIDS Management Guidelines and the 2021 Chinese AIDS Diagnosis and Treatment Guidelines of the Infectious Diseases Branch of the Chinese Medical Association both recommend Bicken Pronorium tablets as the preferred treatment of
HIV.
Director Zhao Wenxuan is not only an expert in HIV treatment, but also an expert
in the Xianyang New Coronary Pneumonia Treatment Expert Group.
In the context of the pandemic, he has been concerned about how to improve medication adherence for
HIV-infected patients.
"It is not realistic to require infected people to come to the hospital frequently for tests such as drug resistance, which increases their risk
of infection.
Therefore, Bickenpronol tablets, which have a high drug resistance barrier and low drug interaction, are undoubtedly the preferred drug regimen for HIV-infected patients in the context of the epidemic, which can greatly reduce
the number of passive trips to and from the hospital for infected people.
"At present, Bicken Pronorol tablets have been recommended by the British AIDS Association (BHIVA) interim guidelines as a first-line drug
for people infected with HIV during the new crown pneumonia epidemic.
[2]
Expert profiles
Professor Zhao Wenxuan
Xianyang Central Hospital
Chief Physician, Master of Medicine
Director of the Infectious Disease Center of Xianyang Central Hospital
Graduated from the Department of Clinical Medicine, School of Medicine, Xi'an Jiaotong University
Expert of the National Advisory Expert Group on Hepatobiliary Diseases
Member of the Liver Disease Committee of the National Association of Research Medical Schools
Member of
the Shaanxi Provincial Severe Hepatitis Science GroupMember of Pediatric Hepatology Group of Shaanxi Health Care Association
Member of Shaanxi Provincial Liver Cancer Professional Committee
Member of Immunohepatology Group of Shaanxi Health Association
Member of the Standing Committee of Shaanxi Society of Venereology
Member of the Shaanxi Province Fever to be Investigated Study Group
Expert of Xianyang New Crown Pneumonia Treatment Expert Group
Research interests: diagnosis and treatment
of various types of hepatitis, cirrhosis, hand, foot and mouth disease, AIDS, hemorrhagic fever and other infectious diseases.
References:
[1] Wohl D, et al.
CROI 2022, Poster 494
[2] BHIVA interim ART guidelines COVID-19 v2 07082020.
Accessed 18 SEP 2020.