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    Home > Active Ingredient News > Drugs Articles > BFS blow-fill sealing machine is currently a aseptic filling process with strong aseptic guarantee ability

    BFS blow-fill sealing machine is currently a aseptic filling process with strong aseptic guarantee ability

    • Last Update: 2022-10-03
    • Source: Internet
    • Author: User
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    BFS blow-fill sealing machine joined the automatic control of in-line cleaning and in-line sterilization technology, BFS equipment in the production of sterile preparations to a large extent to reduce the number of insoluble particles in the product and control the pollution of microorganisms and heat sources, so this can achieve automation, isolation of blow filling and sealing (BFS) technology will be the future development direction
    of sterile preparation production.

    BFS blow-fill sealing machine is a set of special mechanical equipment, under the control of computer programs to complete all material pipelines CIP / SIP (online cleaning / online sterilization), in the same sterile environment under the protection of wind shower, from a thermoplastic particles, complete the liquid preparation container blowing (Blow), filling (Fill), sealing (Seal) of the whole process, to achieve the continuous and automatic process of dosage liquid packaging, Z minimizes the possibility of contamination of products by people and the environment, and is currently an aseptic filling process
    with strong sterility guarantee ability.

    BFS equipment is an advanced system that uses three-in-one (blow-fill-seal) technology to package the liquid medicine in a polypropylene/high-density polyethylene/low-density polyethylene plastic container
    .

    The use of BFS equipment can be done automatically by a single machine in a controlled environment (protected by sterilized filtered air): the plastic particles are extruded through high temperatures; The plastic blank is blown into a container by the air filtered by sterilization; Filling of sterilized and filtered products; Tight sealing of the container after filling; Isolation from human contamination is a significant advantage of BFS, the equipment has a computer that controls the BFS system, and various control valves and sensors are connected to the PLC
    by means of bus control.

    Through these devices, not only can a high degree of automation and reliability of BFS equipment be achieved, but as long as the equipment starts production, no downtime is allowed in the middle; At the same time, it can also be fully connected with the upstream and downstream production systems to achieve automatic and linkage operation
    of multiple systems.

    That is to say, only need to be set on the BFS control computer, you can achieve system regulation
    .

    Thus effectively avoiding human interference with aseptic production, compared with the traditional filling line to provide a high degree of sterility protection
    .

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