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There is such a person around Singularity Cake.
He wants to be addicted to his mouth but is afraid of high calories.
He prefers "sugar-free" and "low-fat" for everything he eats
.
Every time he goes to the supermarket, he asks for a box of sugar-free Coke, and this cake will hold a box of original Happy Sprite, and come back and drink it together
.
Even if you eat Golden Arch, you have to customize the package and choose sugar-free drinks, which is really stressful
.
But as soon as I saw this article, Singularity Cake couldn't wait to share it with this little friend - sugar substitutes that you thought were "sweet and healthy" may cause cancer! Charlotte Debras, from the Research Laboratory for Nutritional Epidemiology (EREB), University Paris XIII, and her colleagues found that high intake of artificial sugar substitutes, especially aspartame, was significantly associated with a 22% higher risk of breast cancer , was significantly associated with a 15% increased risk of obesity-related cancers [1]
.
The article was recently published in the journal Plos Medicine
.
Screenshot of the homepage of the paper The slogan of "sugar removal" has been loudly shouted in the past two years.
Whether from the perspective of health care or anti-aging, sugar-free food is no longer the last choice for diabetics, but has gradually become a major mainstream product.
There are skin care and health products specifically designed to remove sugar
.
As the saying goes, the big tree attracts the wind
.
Many foods are "sugar-free" by adding sugar substitutes with low calories and high sweetness.
As the "sugar-free" turmoil intensifies, people can't help but worry about the drawbacks of sugar substitutes
.
After all, how could previous scientists have imagined that people in the future would ditch real sugar and cheat their sugar cravings by eating a bunch of sugar substitutes.
.
.
Given the harmful health effects of excessive sugar intake, such as weight gain, heart Metabolic disorders, dental caries, etc.
, the World Health Organization (WHO) recommends that the intake of conventional added sugars be controlled within 10% of the daily energy intake [2]
.
However, there are still many controversies about the adverse effects of a large amount of sugar substitutes on human health and how to eat them.
.
Of course, we have to make it clear that sugar substitutes can be divided into artificial sugar substitutes and natural sugar substitutes
.
Common artificial sugar substitutes are aspartame, acesulfame potassium, sucralose, etc.
, and natural sugar substitutes include xylitol, sorbitol, mannitol,
etc.
So far, studies have linked artificial sugar substitutes with obesity, type 2 diabetes, and increased risk of cardiovascular disease [3], while some studies hold the opposite view [4-6]
.
However, there has been no more powerful cohort study on the relationship between artificial sugar substitutes and the king of all diseases-cancer
.
For the study, Charlotte Debras and her colleagues included a total of 102,865 adults (mean age, 42.
2 years) from the French NutriNet-Santé cohort, based on the participants' self-reported 24-hour food consumption records, medical history, education Data such as degree, life>
.
Among these 100,000 people, 18.
46% (n=18987) had higher intake of artificial sugar substitutes, 18.
46% (n=18987) had lower intake of artificial sugar substitutes, and the rest (63.
08 %, n=64892) do not eat artificial sugar substitutes
.
It is worth noting that the "watershed" differs by gender
.
For men, intake of artificial sugar substitutes was higher than 17.
44 mg/day, and for women it was 19.
00 mg/day
.
Among them, sugar-free soft drinks are the main source of intake of artificial sugar substitutes, accounting for 53%
.
In terms of types, the artificial sugar substitutes ingested by the participants were mainly aspartame, accounting for 58.
3% of the total; followed by acesulfame potassium, accounting for 29.
4% of the total, and other artificial sugar substitutes such as sucralose , sodium cyclamate, saccharin, etc.
accounted for a small proportion
.
Left: Unsweetened beverages really dominate.
Right: Acesulfame and aspartame are still eaten a lot.
The analysis results show that compared with those who do not eat artificial sugar substitutes, the intake of aspartame and acesulfame is higher.
were associated with a 15% and 13% increased overall cancer risk, respectively (HR 1.
15, 95%CI 1.
03-1.
28; HR 1.
13, 95%CI 1.
01-1.
26)
.
Specific to specific cancer types, higher intake of aspartame was significantly associated with a 22% increased risk of breast cancer (HR 1.
22, 95% CI 1.
01-1.
48)
.
And there is no escape from "obesity".
Higher intake of aspartame is associated with an increased risk of all obesity-induced cancers (colorectal cancer, stomach cancer, liver cancer, esophagus cancer, ovarian cancer, prostate cancer, etc.
) 15% significant correlation (HR 1.
15, 95% CI 1.
01-1.
32)
.
When no distinction was made, overall, higher intake of artificial sugar substitutes was significantly associated with a 13% increased overall cancer risk compared with no artificial sugar substitutes (HR 1.
13, 95% CI 1.
03-1.
25; P= 0.
002)
.
Top: Overall cancer risk Bottom: Obesity-related cancer risk In summary, Charlotte Debras and her colleagues analyzed data from 100,000 people to show that excessive intake of artificial sugar substitutes (men ≥ 17.
44 mg/day, women ≥ 19.
00 mg/day) is inextricably linked to an increased risk of cancer
.
Although the researchers did not explore the mechanism in depth in this study, this is enough to serve as a warning.
In this era of "sugar-free" pursuit, people urgently need to expand their comprehensive understanding of sugar substitutes
.
At least when consuming sugar-free food, look at the ingredient list more, and don't think "sugar-free = harmless"
.
And how to measure the pros and cons between real sugar, natural sugar substitutes, and artificial sugar substitutes, and how to make trade-offs in the diet, requires scientists to conduct more in-depth and multi-faceted research
.
In the end, Singularity Cake reminds everyone that some studies have shown [7] that sugar substitutes can't actually be "deceived"
.
You have fooled your heart and tongue, but you can’t fool your gut, which still uses nerves to inform your brain—this sugar is fake! However, no matter whether there is sugar or no sugar, with or without steam, Xiao Tianshui is really hard to quit.
.
.
Reference: [1] https://journals.
plos.
org/plosmedicine/article?id=10.
1371/journal.
pmed.
1003950 [2] World Health Organization.
Guideline: sugars intake for adults and children.
Geneva: World Health Organization; 2015 [cited 2022 Mar 2].
https:// Azad MB, Abou-Setta AM, Chauhan BF, Rabbani R, Lys J, Copstein L, et al.
Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies.
CMAJ.
2017; 189 :E929–39.
https://doi.
org/10.
1503/cmaj.
161390 PMID: 28716847[4]Toews I, et al.
Association between intake of non-sugar sweeteners and health outcomes: systematic review and meta-analyses of randomised and non-randomised controlled trials and observational studies.
BMJ.
He wants to be addicted to his mouth but is afraid of high calories.
He prefers "sugar-free" and "low-fat" for everything he eats
.
Every time he goes to the supermarket, he asks for a box of sugar-free Coke, and this cake will hold a box of original Happy Sprite, and come back and drink it together
.
Even if you eat Golden Arch, you have to customize the package and choose sugar-free drinks, which is really stressful
.
But as soon as I saw this article, Singularity Cake couldn't wait to share it with this little friend - sugar substitutes that you thought were "sweet and healthy" may cause cancer! Charlotte Debras, from the Research Laboratory for Nutritional Epidemiology (EREB), University Paris XIII, and her colleagues found that high intake of artificial sugar substitutes, especially aspartame, was significantly associated with a 22% higher risk of breast cancer , was significantly associated with a 15% increased risk of obesity-related cancers [1]
.
The article was recently published in the journal Plos Medicine
.
Screenshot of the homepage of the paper The slogan of "sugar removal" has been loudly shouted in the past two years.
Whether from the perspective of health care or anti-aging, sugar-free food is no longer the last choice for diabetics, but has gradually become a major mainstream product.
There are skin care and health products specifically designed to remove sugar
.
As the saying goes, the big tree attracts the wind
.
Many foods are "sugar-free" by adding sugar substitutes with low calories and high sweetness.
As the "sugar-free" turmoil intensifies, people can't help but worry about the drawbacks of sugar substitutes
.
After all, how could previous scientists have imagined that people in the future would ditch real sugar and cheat their sugar cravings by eating a bunch of sugar substitutes.
.
.
Given the harmful health effects of excessive sugar intake, such as weight gain, heart Metabolic disorders, dental caries, etc.
, the World Health Organization (WHO) recommends that the intake of conventional added sugars be controlled within 10% of the daily energy intake [2]
.
However, there are still many controversies about the adverse effects of a large amount of sugar substitutes on human health and how to eat them.
.
Of course, we have to make it clear that sugar substitutes can be divided into artificial sugar substitutes and natural sugar substitutes
.
Common artificial sugar substitutes are aspartame, acesulfame potassium, sucralose, etc.
, and natural sugar substitutes include xylitol, sorbitol, mannitol,
etc.
So far, studies have linked artificial sugar substitutes with obesity, type 2 diabetes, and increased risk of cardiovascular disease [3], while some studies hold the opposite view [4-6]
.
However, there has been no more powerful cohort study on the relationship between artificial sugar substitutes and the king of all diseases-cancer
.
For the study, Charlotte Debras and her colleagues included a total of 102,865 adults (mean age, 42.
2 years) from the French NutriNet-Santé cohort, based on the participants' self-reported 24-hour food consumption records, medical history, education Data such as degree, life>
.
Among these 100,000 people, 18.
46% (n=18987) had higher intake of artificial sugar substitutes, 18.
46% (n=18987) had lower intake of artificial sugar substitutes, and the rest (63.
08 %, n=64892) do not eat artificial sugar substitutes
.
It is worth noting that the "watershed" differs by gender
.
For men, intake of artificial sugar substitutes was higher than 17.
44 mg/day, and for women it was 19.
00 mg/day
.
Among them, sugar-free soft drinks are the main source of intake of artificial sugar substitutes, accounting for 53%
.
In terms of types, the artificial sugar substitutes ingested by the participants were mainly aspartame, accounting for 58.
3% of the total; followed by acesulfame potassium, accounting for 29.
4% of the total, and other artificial sugar substitutes such as sucralose , sodium cyclamate, saccharin, etc.
accounted for a small proportion
.
Left: Unsweetened beverages really dominate.
Right: Acesulfame and aspartame are still eaten a lot.
The analysis results show that compared with those who do not eat artificial sugar substitutes, the intake of aspartame and acesulfame is higher.
were associated with a 15% and 13% increased overall cancer risk, respectively (HR 1.
15, 95%CI 1.
03-1.
28; HR 1.
13, 95%CI 1.
01-1.
26)
.
Specific to specific cancer types, higher intake of aspartame was significantly associated with a 22% increased risk of breast cancer (HR 1.
22, 95% CI 1.
01-1.
48)
.
And there is no escape from "obesity".
Higher intake of aspartame is associated with an increased risk of all obesity-induced cancers (colorectal cancer, stomach cancer, liver cancer, esophagus cancer, ovarian cancer, prostate cancer, etc.
) 15% significant correlation (HR 1.
15, 95% CI 1.
01-1.
32)
.
When no distinction was made, overall, higher intake of artificial sugar substitutes was significantly associated with a 13% increased overall cancer risk compared with no artificial sugar substitutes (HR 1.
13, 95% CI 1.
03-1.
25; P= 0.
002)
.
Top: Overall cancer risk Bottom: Obesity-related cancer risk In summary, Charlotte Debras and her colleagues analyzed data from 100,000 people to show that excessive intake of artificial sugar substitutes (men ≥ 17.
44 mg/day, women ≥ 19.
00 mg/day) is inextricably linked to an increased risk of cancer
.
Although the researchers did not explore the mechanism in depth in this study, this is enough to serve as a warning.
In this era of "sugar-free" pursuit, people urgently need to expand their comprehensive understanding of sugar substitutes
.
At least when consuming sugar-free food, look at the ingredient list more, and don't think "sugar-free = harmless"
.
And how to measure the pros and cons between real sugar, natural sugar substitutes, and artificial sugar substitutes, and how to make trade-offs in the diet, requires scientists to conduct more in-depth and multi-faceted research
.
In the end, Singularity Cake reminds everyone that some studies have shown [7] that sugar substitutes can't actually be "deceived"
.
You have fooled your heart and tongue, but you can’t fool your gut, which still uses nerves to inform your brain—this sugar is fake! However, no matter whether there is sugar or no sugar, with or without steam, Xiao Tianshui is really hard to quit.
.
.
Reference: [1] https://journals.
plos.
org/plosmedicine/article?id=10.
1371/journal.
pmed.
1003950 [2] World Health Organization.
Guideline: sugars intake for adults and children.
Geneva: World Health Organization; 2015 [cited 2022 Mar 2].
https:// Azad MB, Abou-Setta AM, Chauhan BF, Rabbani R, Lys J, Copstein L, et al.
Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies.
CMAJ.
2017; 189 :E929–39.
https://doi.
org/10.
1503/cmaj.
161390 PMID: 28716847[4]Toews I, et al.
Association between intake of non-sugar sweeteners and health outcomes: systematic review and meta-analyses of randomised and non-randomised controlled trials and observational studies.
BMJ.
