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BeiGene Announces Interim Analysis Results of RATIONALE 303 Clinical Trial of Baizean for the Treatment of Second-line or Third-line Non-Small Cell Lung Cancer

 Last Update: 2021-07-10
 Source: Internet
 Author: User

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In the ITT population, the median OS of the Bazin® test arm was 17.
- In the Bazaan® test arm, 509 patients (95.
  3%) experienced at least one adverse event (TEAE) during treatment, the most common being anemia (28.
  5%) and elevated alanine aminotransferase (ALT; 19.
  9%) ) And cough (19.
  5%)
  .
  In contrast, in the docetaxel test arm, 254 patients (98.
  4%) experienced at least one TEAE, the most common being alopecia (47.
  3%), anemia (43.
  4%), and neutropenia (36.
  8%) )
- 206 patients (38.
  6%) and 193 patients (74.
  8%) of the Bazaan® test arm and the docetaxel test arm experienced grade 3 and above TEAEs, respectively
- 174 patients (32.
  6%) and 83 patients (32.
  2%) experienced severe TEAE in the test arm of Baizen® and the test arm of docetaxel, respectively
- There were 56 patients (10.
  5%) and 32 patients (12.
  4%) in the Baznan® test arm and the docetaxel test arm, respectively, who discontinued the trial treatment due to TEAE
- There were 32 patients (6%) and 11 patients (4.
  3%) died of TEAE in the test arm of Baizen® and the test arm of docetaxel, respectively.
- In the Baizean® test arm, hypothyroidism (7.
  5%) and pneumonia (2.
  2%) were the most common immune-mediated TEAEs of any grade and grade 3 and above, respectively

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