Behavioural Brain Research: The neurophysiological response of safe signals and the role of cardiac ecstic nerve control.

In fear-related disorders such as post-traumatic stress disorder (PTSD), phobias, the shortcomings of safe signal learning are evident.
Current research uses the fear condition reflex paradigm to test the association between winking shock and event-related brain potential (ERP) incubation period safety signal learning measures, as well as the role of cardiac ecstasy nerve control (top-down inhibitions required for safe learning).
post-traumatic stress disorder (PTSD) may not be able to suppress their fear response, and despite the lack of threat, they may experience prolonged awakening and fear.
Similarly, people with panic disorders are flawed in their ability to suppress fear of non-hazardous body sensations and mutual perception of clues (e.g., jumping faster in motion centers), while those with phobias are in a series of non-hazardous objects or situations.
study of these populations shows that poor safety signal learning is a specific esophobia of fear-related diseases that distinguishes them from healthy people.
: The participants were 49 traumatized women between the ages of 17 and 28.
the eye tremor reaction and ERP amplitude/incubation period of conditional stimulation-related (CS-) and unrelevant (CS-) conditional stimuli and aversion to non-conditional stimuli were also deduled.
ERPs include P100 and late positively charged (LPP), which reflect early visual processing and continuous emotional coding, respectively.
heart lost nerve control with resting heart rate variability (HRV).
electro-encephalogram data is processed with BrainVision Analytics 2.04 software (Brain Products, Germany) and refers to average reference values using an offline filter (0.1-30 Hz).
use independent component analysis (ICA) to identify and remove eye movements and eye ring artifacts.
each EEG and EOG channel is amplified by a separate EEG100C and EOG100C module (Biopac MP100C system, Biopac Systems, Goleta, CA) with analog band-pass filters from 0.1 to 35 Hz.
EEG samples (frequency 1khz/s) are sampled at a frequency of 1khz/s.
use AcqKnowledge 3.8.1 to collect EEG and EOG data for the Biopac MP100C system.
results: P100 and LPP incubation period CS-(safe signal stimulation) was significantly negatively associated with shock, but not CS-plus.
LPP-CS-incubation period was significantly negatively associated with post-traumatic stress disorder scores, a relationship regulated by ecstic nerve control, so the effect was only present in people with lower HRV.
: ERP-based safety signal learning markers are associated with a panic response to CS-(but not CS-plus) and PTSD symptoms, suggesting that these markers may be associated with fear-related diseases.
heart's ecstransitic nerve control, which is an indicator of heart rate variability, is a regulatory factor in these connections and may be associated with safe signal learning.
Seligowski, A.V., et al., Neurophysiological responses to safety signals and the role of cardiac vagal control. Behavioural Brain Research, 2021. 396: p. 112914. MedSci Original Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that indicate "Source: Mets Medicine" or "Source: MedSci Originals" are owned by Metz Medicine and are not authorized to be reproduced by any media, website or individual, and are authorized to be reproduced with the words "Source: Met Medical".
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