Behavioural Brain Research: Drd2rs6277 Polymorphism, Environment, and Gender Interactions on Impulsiveness in Representative Population Studies

Impulsivity is a multi-dimensional behavior and personality structure characterized by a lack of thinking and a tendency to act quickly and planlessly.
impulsive behavior is considered to be caused by impaired executive function and is the result of dysfunctional inhibition processes and strong impulses (also known as desires, impulses, or habits), triggered and regulated by situational and personality factors.
tendency to act impulsively is found in psychiatric conditions such as substance use disorders, attention deficit/ADHD, borderline and antisexual personality disorders, and schizophrenia.
addition, emotional and behavioral self-control is at the heart of the problems described in the section "Destructive, Impulsive Control and Behavioral Disorders" in the Manual of Diagnosis and Statistics of Mental Disorders.
Impulse behavior may be regulated by several neurotransmitter systems in the brain, including 5-serotonin, epinephrine, choline, and dopamine, and sephroid and proletail dopamine abnormalities are the most common studies.
the purpose of this study is to explore the role of gender in these results by further investigating the relationship between DRD2 rs6277 and early adversity of behavior and self-reporting impulses, as well as alcohol use in a representative sample of populations.
Hypothesis as DRD2 rs6277 polymorphic CC pure co-ed, and experienced a large number of stress life events (SLE) and/or domestic abuse before the age of 15 led to: 1) self-reported poor adaptive impulsivity, 2) reduced adaptive impulsivity, 3) poor behavioral impulsivity test.Second, assuming warm family relationships helped: 1) lower inability to adapt to impulses, 2) higher scores on adaptive impulses, and 3) CC pure thyspoets performed better on behavioral impulse tests than other groups.
, however, because estrogen may provide neuro protective effects, women are expected to show less effective environmental events in behavioral and self-reported impulsive measurements than men.
a second purpose, this paper explores the association between DRD2 rs6277 genotypes and personality traits, as it is thought that impulsiveness may be influenced by the traits of others in the individual.
in the first round of the study, the average age of the younger group was 9.6 years (SD -0.5278 males, 305 females).
follow-up time was in 2004 (n=483, MAge=15.3±0.5, male 222, female 261), 2007 (n=454, MAge=2 18.3±0.5, Male 202, Female 252) and 2014 (n=440, MAge=25.3±0.5, Male 193, Female 247).
adaptive and impulsive scales (AMIS) are used to measure impulsive self-reporting in each study wave.
378 15-year-olds were tested for visual comparison (VCT).
computer-based stimulation, consisting of multiple X geometry.
the graphic is paired with another graphic to form the same or different graphic pairs.
in the same pair, the two numbers are the same.
in different pairs, the position of a single X changes on the periphery of the graph.
and adolescents with systemic lupus erythematosus is self-reported at the age of 15.
Systemic lupus includes 21 adverse experiences, such as parental death and divorce/separation, parental unemployment, absence of both parents, economic problems, poor living conditions and family poverty, poor health, chronic diseases, death of close relatives, serious illness of family members, family humiliation, fear of school and school bullying.
family relationships were measured using the Children's Reporting Tartu Family Relationship Scale, which measured intimacy, support, misunderstanding and (emotional and physical) abuse.
because of the correlation between the weight scales, intimacy and support can be added together to form a higher-order scale called family warmth.
follow-up study, subjects reported the age at which they first drank half a unit of alcohol.
unit of alcohol is defined as a glass of light wine or champagne (12 ml), a glass of vodka (4 ml) or a bottle (33 ml) of light alcohol (beer, long drink, cider, etc.).
the average thoughtless score of the three study curves was not able to determine the genotype of a participant based on the median division of DRD2 genotypes and warmth.
, genotype distribution did not deviate from hardy-Weinberg balance (TT=157, TC=273, CC=149; X2=1.87,df There was no significant correlation between the DRD2 genotype and the rate of systemic lupus erythematosus (SLE) and the family relationship questionnaire score .
did not find any significant major effects of DRD2 on impulse or alcohol use measurements.
the full results of GEE analysis using DRD2 rs6277 genotypes, genders, and SLE for self-reported impulsive measurements in three studies.
GEE analysis showed that in three studies, there were significant three-factor interactions (χ2-5.567, p-0.062) on the effects of non-thinking in three studies, and in separate studies, variance analysis showed significant three-factor interactions (DRD2×SLE× gender interactions) on the effects of thoughtlessness at age 25.
two groups of subjects did not find significant DRD2×ELS interaction, p.gt;0.05.
in all study waves, DRD2×SLE had a slightly significant effect on two-way interactions that were not adapted to impulses (GEE; χ2-5.537, p-0.063), which was 15 At the age of the year, F (2,461) was 4.760, p was 0.009, and part η2 was 0.020, π was 0.792.
there was no significant three-way interaction between DRD2 genotypes, gender, and warmth in the combined scores of adaptive or adaptive impulses.
analysis of SST results shows that the interaction of DRD2×SLE is slightly significant in delegate error, F (2338) s 2.438, p s.089, part η2 s.014 On π, on SSRT, F (2308) is 2.677, p is .070, part η2 is .017, π is .529.
DRD2 genotype F (2,338) s 2.591, p s.076, part η2 s.017, π s.515 on the average Go reaction time also has a slightly significant main effect, CC pure healer slower than TC hethion and TT pure healing.
GEE with DRD2 genotype, systemic lupus erythematosus, and sex as predictors showed slightly significant DRD2× systemic lupus interaction in the study wave (χ2 s 4.9 71, p-0.083), and three-factor DRD2×sysysic lupus erythematosus× gender interaction (χ2 s 5.007, p s 0.082).
this study showed that DRD2 rs6277 polymorphism interacted with SLE and family environments in affecting self-reporting impulses, and CC pure thygos generally exhibited a high degree of ill-adaptive impulses in adverse environments.
, on the other hand, there is some evidence that CC carrier men benefit from supportive family relationships by showing lower levels of indissor.
interaction between genotypes and the environment, as well as further interactions with gender, is also evident in drinking habits.
results of behavioral impulse tests showed that the interaction × DRD2 and SLE was only slightly significant.
K. Klaus, M. Vaht, K. Pennington, J. Harro, Interactive effects of DRD2 rs6277 polymorphism, environment and sex on impulsivity in a population-representative study, BehaviourAl Brain Research, Volume 2 403, 2021, 113131, MedSci Original Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that indicate "Source: Mets Medicine" or "Source: MedSci Originals" are owned by Mets Medicine and are not authorized to reproduce, and any media, website or individual authorized to reproduce them must indicate "Source: Mets Medicine".
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