 Home > Biochemistry News > Biotechnology News > Bao Lan's team collaborated to reveal the influence of α-tubulin subtypes (α1A and α1C) on the dynamics of microtubules

Bao Lan's team collaborated to reveal the influence of α-tubulin subtypes (α1A and α1C) on the dynamics of microtubules

 Last Update: 2021-11-13
 Source: Internet
 Author: User

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Microtubules are an important component of the cytoskeleton and participate in various life activities such as intracellular material transportation, cell migration, polarity establishment and morphological maintenance

Alpha-tubulin and beta-tubulin are expressed in all eukaryotes, and there are many subtypes

In this study, the author first used insect cells to express and purify the three members of the tubulin α1 family (α1A, α1B, and α1C), which were combined with the same ubiquitously expressed β-tubulin subtype (β2A), That is, α1A/β2A, α1B/β2A, and α1C/β2A

Researcher Bao Lan from the Center for Molecular Cell Excellence and Associate Professor Liang Xin from Tsinghua University are the corresponding authors of this article.

Article link: https://academic.

Microtubules composed of α1A/β2A and α1C/β2A have different dynamics and EB1 binding characteristics

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