Macrophages (green) surround intestinal neurons (red) Image source: Rockefeller University
Macrophages (green) surround intestinal neurons (red) Image source: Rockefeller University Macrophages (green) surround intestinal neurons (red) Image source: Rockefeller University A simple stomach disease can cause great harm to people
A new study found that mice infected with bacteria or parasites develop a unique form of tolerance that is completely different from the immune response in textbooks
The study, published in Cell, describes how intestinal macrophages can shield intestinal neurons to prevent them from dying when pathogens attack in the future
"What we describe is an innate memory that still exists after the original infection disappears
The enteric nervous system is called the "second brain" of the body and is the largest pool of neurons and glial cells outside the brain
Postdoctoral fellow Tomasz Ahrends and other laboratory members first infected mice with non-lethal Salmonella strains
Researchers have discovered that during a primary bacterial infection, neurons will call out to macrophages, and the macrophages will rush to the area to protect their fragile cells from future attacks
Mucida also hopes to determine the exact effect of neuron loss on the gastrointestinal tract
Related paper information: https://doi.
https://doi.
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