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Image: Representative flow plots of mucosa-associated invariant T cells (MAITs) in CD69+ granzyme B+ (GrB+)-activated peripheral blood mononuclear cells (pmcs) showing a -6-D nucleoside amine uracil (5-P-RU) or bile and anti-MR1 antibody or isotype control after incubation
Source: The American Journal of Pathology
Primary sclerosing cholangitis (PSC) is a disease in which inflammation leads to scarring of the bile ducts, leading to liver failure, infection and tumors
The bile microbiota is considered to be a major factor or important regulator of PSC
"It was recently reported that a unique group of bacteria is present in the bile of PSC patients, and we wanted to explore whether bile contains major histocompatibility complex class I-related gene protein (MR1)-restricted antigens that can be processed by cholangiocytes and presented to MAIT cells to initiate or modulate immune responses in inflammatory bile diseases," Dr.
To investigate the presence of potential MAIT cell antigens in the bile of PSC patients, we screened bile from 28 patients collected at the time of PSC liver transplantation using flow cytometry analysis of peripheral blood mononuclear cells from healthy donors
The researchers also examined bile from seven patients with other chronic liver diseases to determine whether the presence of MAIT antigens in bile was specific to patients with PSC
To determine whether MAIT cell-activating antigens were derived from microorganisms, all 35 bile samples in this study were screened by genetic sequencing
Dr.
article title
Bile from Patients with Primary Sclerosing Cholangitis Contains Mucosal-Associated Invariant T-Cell Antigens
